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乙型和丙型肝炎病毒重叠感染的研究 |
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陈宪锐 吴多文 尹燕明 张玉江 周玉霞 玄梅香 魏佑农 付春生
摘要：目的为了解乙型肝炎患者重叠感染丙型肝炎病毒(HCV)的状况，并探讨乙型肝炎病毒(HBV)、HCV重叠感染时HCV对HBV复制的影响。方法 应用ELISA法对712例乙型肝炎患者进行了血清抗-HCV检测和乙型肝炎病毒标志检测。结果 712例乙型肝炎患者血清抗-HCV阳性率为14.47%，其中重型肝炎患者血清抗-HCV阳性率最高(48.98%)，急性肝炎患者最低(3.25%)。在不同临床类型的乙型肝炎患者之间，血清抗-HCV阳性率存在显著性差异(P＜0.001)，显示病情越重，病程越长，血清抗-HCV阳性率越高；在HBV和HCV重叠感染的患者中，血清HBsAg、HBeAg和抗-HBcIgM阳性率低于乙型肝炎患者(P＜0.001，P＜0.001和P＜0.05)，而血清抗-HBe阳性率高于乙型肝炎患者(P＜0.01)，均有显著的统计学意义。结论 乙型肝炎患者重叠感染HCV与病情加重和慢性化的形成有关，并使HBV的复制受到抑制。
关键词：乙型肝炎病毒 丙型肝炎病毒 丙型肝炎病毒抗体
Study of superinfection of HBV and HCV
CHEN Xianrui*,XUAN Meixiang,WU Duowen,et al.
Taishan Medical College，Shandong Province 271000
Abstract Objectives To understand the situation in hepatitis B patients coinciding with HCV and to explore its influence on HCV on the replication of HBV. Methods Using ELISA,712 hepatitis B patients were tested for serum anti-HCV and markers of HBV. Results Of the 712 patients, anti-HCV positive rate was 14.47% with the highest 48.98% in patients with severe hepatitis and the lowest 3.25% in patients with acute hepatitis. Markedly different anti-HCV positive rates (P＜0.001) in patients of different clinical stages were discovered. The more severe the case with longer the course, the higher the anti-HCV positive rates. In patients with superinfection of HBV and HCV, serum HBsAg,HBeAg and anti-HBcIgM positive rates were lower than those in patients with hepatitis B (P＜0.001,P＜0.001 and P＜0.05) but the anti-HBe positive rates were higher. All the differences showed an obvious statistical significance. Conclusion Hepatitis B coinciding with HCV infection is responsible for the deterioration of the disease and towards its formation of its chronic phase as well as for the inhibition of HBV replication.
key words HBV HCV Anti-HCV
在病毒性肝炎患者中，慢性肝炎和重型肝炎患者多为乙型肝炎，而在部分患者血清中可测出抗-HCV。为了解乙型肝炎患者重叠感染HCV的状况，并探讨HBV和HCV重叠感染时HCV对HBV复制的影响，1996年2月至1998年8月对712例乙肝患者进行了血清抗-HCV检测，并对其血清乙肝病毒标[1] [2] [3] 下一页
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