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不同频率及功率密度毫米波辐射对子代的影响 |
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赵志刚 吴芬芳
【摘要】 目的 确定毫米波导致胚胎损伤阈值及仔鼠学习记忆功能降低的机理。方法 用37.4、42.2、53.0和60.0 GHz，功率密度1～8 mW/cm2 毫米波，在小鼠怀孕6～15天时每天进行2小时辐射，用电迷宫对仔鼠进行学习记忆功能测试，用受体放射配基分析、高效液相色谱-电化学检测和放射免疫法对仔鼠脑M-胆碱能受体、单胺递质和精氨酸加压素（AVP）进行测定。结果 37.4、42.2 GHz 和53.0、60.0 GHz毫米波导致仔鼠学习记忆功能降低、海马区最大受体结合数增加、脑多巴胺（DA）下降的最小功率密度分别为5和3 mW/cm2，导致成年子鼠下丘脑内AVP降低的最小功率密度分别为8和5 mW/cm2。随功率密度增加，辐射导致胎仔损伤程度加重。毫米波未使孕鼠体温升高。结论 37.4、42.2 GHz和53.0、60.0 GHz毫米波导致胚胎损伤阈值分别为3～5 mW/cm2和1～3 mW/cm2， 其导致仔鼠学习记忆功能降低与其脑中AVP、DA含量下降及海马区胆碱能神经活性降低相关，此效应由毫米波非热效应所致，未见毫米波的频率特异性。
【关键词】 微波 辐射损伤 胚胎
Effects of Millimeter Wave Irradiation with Different Frequency and Power Density on Their Offsprings in Mice
Zhao Zhigang, Wu Fenfang. Department of Respiratory Disease, No. 201 Hospital, PLA, Dalian 116021
【Abstract】 Objective To determine the threshold of millimeter wave irradiation leading to fetal damage in mice and to clarify the mechanism of decrease in their learning and memory function. Methods Pregnant mice were irradiated by millimeter wave with frequencies of 37.4, 42.2, 53.0 and 60.0 GHz at power densities of 1 to 8 mW/cm2 for two hours daily from the 6th to 15th day of their gestation. Learning and memory functions of their offsprings were tested by a Y-type electric maze. M-cholinergic receptor (M-R), monoamine transmitter and arginine vasopressor (AVP) in the brain were determined for their offsprings by receptor radiation binding analysis (RBA), high performance liquid chromatography-electrochemical detection (HPLC-ECD) and radioimmunoassay (RIA). Results The minimal power density of millimeter wave of 37.4, 42.2, and 53.0, 60.0 GHz causing the decrease in learning and memory function, increase of Bmax in the hippocampus and decrease in dopamine (DA) in the brain of the adult offspring mice was five and three mW/cm2 and that causing the decrease in AVP in the hypothalamus was eight and five mW/cm2. Severity of damage in fetal offspring mice caused by irradiation increased w[1] [2] [3] 下一页
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