|
滥用酒精与抗氧化剂和抗氧化酶的关系 |
|
周君富 杜雨红 王也玲 彭芬英 丁德云
【摘要】 目的 探讨滥用酒精与抗氧化剂、抗氧化酶和氧自由基反应的关系。方法 用分光光度比色分析法分别检测194例40岁男性滥用酒精者和50例40岁男性无饮酒史健康者血浆维生素C、维生素E和β-胡萝卜素含量以及红细胞超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性。结果 滥用酒精者的上述检测值均随饮酒年限延长和饮酒量增加而逐渐降低。结论 滥用酒精者体内的氧自由基反应病理性加剧,氧化和抗氧化平衡严重失调。 【关键词】 酒精中毒 抗坏血酸 维生素E β-胡萝卜素 超氧化物歧化酶 过氧化氢酶 谷胱甘肽过氧化酶
The Correlation between Abusing Alcohol and Antioxidants, Antioxidases
Zhou Junfu, Du Yuhong, Wang Yeling, et al. The 2nd Hospital of Zhejiang Medical University,Hangzhou 310009
【Abstract】 Objective To study the correlation between abusing alcohol and antioxidants, antioxidases and oxygen free radical reaction. Methods We measured spectrophotometrically the plasma vitamin C(P-VC), plasma vitamin E(P-VE), plasma β-carotene (P-β-CAR) contents and erythrocyte superoxide dismutase (E-SOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxidase(E-GSH-Px) activities in 194 male (40 years old) alcohol abusers and 50 male(40 years old) nondrinkers. Results The average P-VC, P-VE, P-β-CAR contents and E-SOD, E-CAT, E-GSH-Px activities of the alcohol abuser group were lower than those of the nondrinker group . The P-VC, P-VE, P-β-CAR contents and E-SOD, E-CAT, E-GSH-Px activities of the alcohol abusers decreased as the time and quantity of abusing alcohol increased. Conclusion The oxygen free radical reaction in the alcohol abusers was pathologically exacerbated, and the balance between oxidation and antioxidation was serious imbalanced.
【Key words】 Alcoholism Vitamin C Vitamin E β - Carotene Superoxide dismutase Catalase Glutathione peroxidase
酒精可供给一定热量,但不含任何营养成分。我国自80年代以来,酒精滥用问题日趋严重[1~3]。为探讨滥用酒精者体内的氧自由基反应及氧化和抗氧化平衡状态,我们检测了194例40岁男性滥用酒精者[1]和50例40岁男性无饮酒史健康者的血浆维生素C(P-VC)、血浆维生素E(P-VE)、血浆β-胡萝卜素(P-β-CAR)含量和红细胞超氧化物歧化酶(E-SOD)、红细胞过氧化氢酶(E-CAT)、红细胞谷胱甘肽过氧化酶(E-GSH-Px)活性,并作比较;同时,对滥用酒精者饮酒年限、饮酒量与上述各检测值的趋势检验作了分析,报告如下。
对象与方法
[1] [2] 下一页 上一个医学论文: 应用氢呼气试验测定食物口 下一个医学论文: 十株产色素非O1群霍乱弧菌的发现与研究
|
|
|
|
|
|
|