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血管紧张素 在自发性高血压大鼠主动脉重建中的作用 |
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冀凯宏 姜宗来 杨向群 章建梁
［摘 要］ 目的：探讨血管紧张素Ⅱ（AngⅡ）在高血压主动脉重建中的作用。方法：选用AngⅡ受体I亚型拮抗剂losartan，对雄性自发性高血压大鼠（SHR）进行为期10周的治疗，观察并比较其在剂量15 mg/kg.d-1及0.75 mg/kg.d-1时，对16周到26周SHR胸主动脉重建的影响。结果：Losartan 15 mg在降低血压的同时, 通过抑制主动脉中膜平滑肌细胞(VSMC)的肥大明显抑制了主动脉肥厚,losartan 0.75 mg未能使血压下降的情况下，对VSMC及主动脉肥厚均没有影响。Losartan对胶原纤维的作用与对VSMC的作用不同，两种剂量的losartan均明显抑制了胶原纤维的合成。结论：AngⅡ对SHR主动脉平滑肌生长的调节可能为压力依赖性，对胶原纤维的作用则可能是通过非压力机制。
［主题词］ 高血压； 血管； 血管紧张素Ⅱ; 肌，平滑，血管； 细胞； 胶原
［中图分类号］ R 544.1 ［文献标识码］ A
［文章编号］ 1000-4718(2000)03-0214-04
Effect of angiotensin Ⅱ on the remodeling of aorta in spontaneously hypertensive rats
JI Kai-hong, JIANG Zong-lai , YANG Xiang-qun , ZHANG Jian-liang
(Department of Anatomy, Institute of Biomedical Engineering,Second Military Medical University, Shanghai 200433, China)
［Abstract］ AIM: To investigate the effects of a 10-weeks treatment with angiotensin Ⅱ (Ang Ⅱ) subtype I receptor antagonist losartan on vascular remodeling of thoracic aorta in male spontaneously hypertensive rats (SHR). METHODS: SHR were treated from 16 to 26 weeks of age with losartan at 15 mg/kg.d-1 or 0.75 mg/kg.d-1. RESULTS: Losartan (15 mg/kg.d-1) treatment significantly decreased systolic blood pressure compared with the control group, while losartan (0.75 mg/kg.d-1) had no the effect, losartan(15 mg) prevents the development of aortic hypertrophy by preventing hypertrophy of vascular smooth muscle cells (VSMC). In the losartan 0.75 group, these parameters were not changed. But in the losartan 15 and losartan 0.75 groups, the collagen content of the aortic media decreased significantly. CONCLUSION: It is inferred that the effect of Ang Ⅱ on stimulating VSMC growth of the aorta in SHR is dependent on arterial pressure, while the effect on collagen fibers is through pressure independent mechanism.
［MeSH］ Hypertension; Blood vessels; Angiotensin Ⅱ; Muscle, smooth, vascular; Cells; Collagen
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