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儿童单纯性肥胖症与肥胖基因表达产物的关系 |
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栾佐 赵云涛 刘淑英 高连如 李莉 张肇康
【摘要】 目的 探讨肥胖基因表达产物肥胖蛋白（OP）与儿童单纯性肥胖症发病及预后的关系。方法 采用放射免疫分析检测30例单纯性肥胖症和21例正常儿童血浆OP含量，所有血浆标本检测前均经Sep-pak C18 Cartridge提取。结果 肥胖组血浆OP含量（118.53±25.02）ng/L较对照组(197.14±26.83) ng/L显著减少。肥胖组中有3例OP含量低于检测水平，3例仅为（19.9±3.94）ng/L。这些重度OP缺乏肥胖儿不仅身高体重指数、总胆固醇、甘油三酯、低密度脂蛋白-胆固醇含量增多，而且综合治疗后有效率（16.67%）亦明显低于OP轻度缺乏肥胖儿（79.16%）。结论 提示单纯性肥胖症儿童缺乏OP，肥胖的发生可能与此有关。严重缺乏OP的肥胖儿疗效差，预后不佳。
【关键词】 肥胖症 蛋白质类 基因表达 儿童
Relationship between Obese Gene Expressive Product and Simple Obesity in Children LUAN Zuo*, ZHAO Yuntao, LIU Shuying, et al. *Department of Pediatrics The Navy General Hospital, Beijing 100037
【Abstract】 Objective To investigate the relationship between obese gene expressive product-obese protein (OP) and the pathogenesis and prognosis of simple obesity in 30 children with normal body weight (control group). Methods Before immunoassay, OP was extracted from the whole blood samples with Sep-pak C18 Cartridge. Results The plasma contents of OP in the obese group were (118.53±25.02) ng/L and (197.14±26.83) ng/L (P<0.001), respectively. In the obese group, plasma OP was not detected in three cases and was (19.90±3.94) ng/L in other three cases. These obese children with severe OP deficit not only had more increased body mass index, and levels of total cholesterol, triglyeride and low-density lipoprotein-cholesterol, but also had lower therapeutic effect (16.67%) than those with mild OP depletion (79.16%). Conclusion The children with simple obesity have OP deficit. Simple obesity may be related with the reduced plasma content of OP. The obese children with severe OP deficit have poorer curative effect and unfavorable prognosis.
【Key words】 Obesity Proteins Gene expression Children
据80年代统计，我国儿童单纯性肥胖症的发生率约3％～5％，近年来逐年递增，但其发生机制一直不明。1991年，国外发现肥胖基因。1994年，克隆肥胖基因成功。随后又发现其表达产物肥胖蛋白（obese protein，OP），证实OP作为肥胖基因编码的循环因子具有抗肥胖作用［1，2］。肥胖基因及其表达产物的发现对于研究人的肥胖发生机制是一[1] [2] 下一页
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