|
阿霉素前体脂质体对大鼠心肝毒性及对实验性肿瘤的作用 |
| |
郭青龙 丁启龙 朱家璧 郑稳生
摘 要 目的：研究阿霉素前体脂质体［doxorubicin(DR)，proliposome(PL),DRPL］对大鼠心肝毒性及对荷瘤小鼠的抗肿瘤活性。方法：以酶活性变化为指标，结合病理组织学检查，观察药物对大鼠的心肝毒性及荷瘤小鼠的生命延长率和药物的抗肿瘤活性。实验动物分为DRPL组和DR组，其中2.00，1.40，0.98 mg.kg-1对应剂量观察药物对大鼠的毒性；4，2，1 mg*kg-1对应剂量观察药物的抗肿瘤活性。结果：与DRPL相比，DR可明显增加大鼠血清LDH、CK、GPT及GOT的活性，DRPL对大鼠心肌细胞的损伤明显小于DR。相同剂量间相比DRPL延长腹水型小鼠移植瘤EAC、Heps的存活天数明显高于DR。结论：DRPL对大鼠心肝毒性明显小于相同剂量的DR，DRPL不但保持了DR的抗肿瘤活性，而且有明显增效作用。
主题词 阿霉素；脂质体；心脏；肝脏；药物筛选试验，抗肿瘤
The effect of doxorubicin proliposome on toxicity of liver and
heart in rats and experimental tumour
GUO Qing-Long, DING Qi-Long, ZHU Jia-Bi1, ZHENG Wen-Sheng1
Department of Physiology, 1 Department of Pharmaceutics, China Pharmaceutical University, Nanjing(210009)
Abstract AIM：To study the cardiac and heratic toxicities and the antitumor activity of doxorubicin(DR) proliposome(PL)［DRPL］.METHODS：The activity of enzymes and the histopathological lesions of the tissues were observed to study the toxicities of DRPL and DR, while the survival rate of mice with tumor was recorded to evaluate their antitumor activity. The animals were devided into DRPL or DR groups. The toxicities and the antitumor activity of them were compared at the doses of 2.00, 1.40, 0.98 mg*kg-1 and 4, 2, 1 mg.kg-1,respectively.RESULTS：Compared with DRPL, DR significantly increased the activities of LDH,CK,GPT and GOT in serum of rats. DRPL significantly reduced the lesions in heart. With the same dose, DRPL could prolong the survival time of mice with EAC,Heps of ascitic more significantly than DR. CONCLUSION：The cardiac and hepatic toxicities of DRPL were much less serious than those of DR. DRPL not only remained but also significantly strengthened the antitumor activity of DR.
MeSH Doxorubicin; Liposomes; Heart; Liver; Drug screening assays, antitumor
阿霉素(doxorubicin,DR)是一种蒽醌类抗生素，临床上用于治疗多种肿瘤疾病。因其有多方面的副作用，如骨髓抑制表现为白细胞和血小板减少；心脏毒性表现为早搏、室速和传导阻滞等心电图改变以及心肌病理和生化方面的变化。肝脏毒性表现为肝细胞坏死引起的酶学改[1] [2] 下一页
上一个医学论文： 胎肝提取物对培养中4株肝癌细胞增殖和分化的影响
下一个医学论文： 大鼠主动脉内膜球囊剥脱后再生内皮细胞表型改变的研究
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文