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硝苯地平控释片与5 |
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李勇 戚文航 范维琥 张娟赢
【摘要】 目的 比较硝苯地平控释片与5-单硝异山梨醇酯对稳定性心绞痛的疗效。方法 53例稳定性心绞痛患者停用抗心绞痛药物1周，然后经2～3周的单盲安慰剂治疗后，进入为期6周的单盲随机对照试验，以平板运动负荷心电图为考察指标。结果 经过6周的治疗后，硝苯地平控释片（30mg，每日1次）与5-单硝异山梨醇酯（20mg，每日2次）均能显著减少心绞痛发作次数（分别下降87％和51％，P<0.05）及硝酸甘油消耗量（分别下降91％和54％，P<0.05）；提高运动能力，延长运动时间（分别延长114秒和25秒，P<0.01），且对运动能力的改善作用分别在末次服药（疗程结束）后24小时和12小时仍然存在。结论 硝苯地平控释片和5-单硝异山梨醇酯均能有效改善稳定性心绞痛患者的临床症状，心电图及运动能力，其有效作用分别持续24和12小时。
【关键词】 心绞痛，稳定性 硝苯地平，控释片 异山梨醇酯
Comparative efficacy of nifedipine gastrointestinal therapeuticsystem versus isosorbide mononitrate in patients with stable angina pectoris
LI Yong QI Wenhang FAN Weihu et al
Departments of Cardiology, Huashan Hospital, Shanghai Medical University, Shanghai 200040
and Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025.
【Abstract】 Objective To assess the efficacy of nifedipine gastrointestinal therapeutic system (nifedipine GITS) and isosorbide mononitrate (ISMN) in patients with stable angina pectoris. Methods After withdrawing the anti-angina drugs for one week, 53 patients with stable angina pectoris received placebo single-blindly for 2-3 weeks, and then entered the study using a randomized, single-blind design to compare the effects of nifedipine GITS and ISMN on treadmill exercise tolerance test during a 6-week period. Results Both nifedipine GITS, 30mg, once daily and ISMN, 20mg, twice daily reduced angina pectoris attacks (-87% and -51%, respectively, P<0.05) and nitroglycerin consumption (-91% and -54%, respectively, P<0.05); improved the parameters of treadmill exercise tolerance test with prolonging the total exercise time (114 and 25 seconds, respectively, P<0.05), and the improvements were last at least 24 and 12 hours after nifedipine GITS and ISMN administrated, respectively. Conclusion Nifedipine GITS as well as ISMN is able to ameliorate clinical symptoms, ischemic changes in electrocardiogram and exercise tolerance tests[1] [2] 下一页
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