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急性心肌梗塞患者血脂水平分析 |
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梁金锐 沈潞华 于俊民 朴圣淑
【摘要】 目的 探讨急性心肌梗塞(AMI)患者的血脂水平及其对患者近期预后的影响。方法 对447例AMI患者入院时的血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、血清脂蛋白(a)[Lp(a)]、血浆氧化低密度脂蛋白(OX-LDL)进行测定,并根据患者年龄、是否吸烟,有无合并糖尿病、高血压病进行分组,比较各组间的血脂与预后关系。同时对患者住院4周内死亡风险与其影响因素采用Logistic回归进行分析。结果 心肌梗塞急性期TG≥2.2mmol/L者占13%,TG在1.76~2.2mmol/L者占12%;TC≥6.24mmol/L者占16%,TC在4.68~6.24mmol/L的患者占40%。多元Logistic回归分析发现:TC、LDL-C是预测心肌梗塞急性期死亡的独立危险因素。结论 心肌梗塞患者急性期即可发现高脂血症。总胆固醇、低密度脂蛋白-胆固醇水平是最重要的心肌梗塞急性期死亡的独立危险因素。 【关键词】 心肌梗塞 脂类
Plasma-lipid changes after acute myocardial infarction
LIANG Jinrui SHEN Luhua YU Junmin et al Department of Cardiovascular Medicine, Beijing Friendship Hospital, Beijing 100050
【Abstract】 Objective The purpose of this investigation was to discover the serum-lipid level on the morning after acute myocardial infarction (AMI) and its relationship with smoking, diabetic mellitus (DM), hypertension, and the prognosis. Methods Plasma -cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), lipoprotein (a) [Lp(a)], oxidatively modified low density lipoprotein (OXLDL) were measured in 447 patients with proven acute myocardial infarction (AMI).Results In 13% of patients was the TG level increased. In 16% of patients was the TC level raised. The patients with increased Lp(a) level were characterized by a cluster of risk factors such as smoking and diabetic mellitus. Multiple analysis showed that increased TC, LDL-C were positively correlated with cardiac death in hospital. Conclusion Serum-lipid disorders were correlated with poor prognosis of AMI. 【Key words】 myocardial infarction lipids
急性心肌梗塞威胁着人类生命,出现梗塞后并发症和致死性原因是多方面的[1]。本文就急性心肌梗塞(AMI)患者的血脂水平与其年龄、性别、吸烟、糖尿病、高血压病之间的关系进行分析,并初步探讨血脂水平对AMI患者近期预后的影响。
资料与方法
1991年5月至1996年5月收入本院CCU病房的AMI患者(诊断标准按WHO)。选血脂资料完整者447例,其中男性338例,年龄25~83岁,平均年龄57.3岁;女性109例,年龄50~85岁,平均年龄64.9岁。[1] [2] [3] 下一页 上一个医学论文: 纤维蛋白原基因启动子区Hae 多态性和血浆纤维蛋白原浓度与冠心病的相关性研究 下一个医学论文: 硝苯地平控释片与5
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