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静脉注射依那普利拉治疗重症高血压的疗效及安全性 |
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郭冀珍 陆德澄 赵福全 杨菊贤 杜俭
【摘要】 目的 验证国产依那普利拉(E)治疗重症高血压的降压疗效及安全性，以提供高血压急症的新药。方法 对上海、镇江、扬州等4家医院收治的172例高血压病重症患者，男118例，女54例，平均年龄（53±9）岁，静脉注射E。分组：（1）对三组高血压病(各10例)分别静脉注射E 1.25 mg、2.5 mg、5 mg；（2）E与甲磺酸酚妥拉明(P)各54例单次静脉注射开放平行比较试验；（3）34例为24小时内多次静脉注射E(q6h)，观察24小时内血压、心率及不良反应。结果 结果显示：（1）不同剂量E静脉注射以2.5 mg降压效果最好；（2）两组比较：用药后2、4、6小时E组降压幅度优于P组(P<0.05)，总有效率为96.3％，P组总有效率90.7％；（3）24小时多次给E，总有效率达100％。E主要不良反应：轻度头昏(6/118)、头痛(2/118)、肢体麻木(4/118)及咳嗽(5/118)。结论 国产E是一种安全有效的治疗高血压急症用药，我们推荐静脉首选剂量2.5mg为宜。
【关键词】 依那普利拉 高血压，恶性 治疗结果
Effect of intravenous enalaprilat on severe essential hypertension GUO Jizhen, LU Decheng*, ZHAO Fuquan**, et al. Ruijin Hospital and Shanghai 9th Hospital of Shanghai Second Medical University, Shanghai 200025 Zhenjiang Medical College Affillated Hospital, Zhenjiang 212001 ** Yangzhou Medical College Affillated Hospital, Yangzhou 225000
【Abstract】 Objective To evaluate the acute antihypertensive effect and safety of intravenous administration of enalaprilat. Methods 172 patients with severe hypertension (DBP≥120 mm Hg, 118 male, 54 female, mean age 53±9 years old )were admitted to four hospitals which are in Shanghai, and Zhenjiang and Yangzhou in Jiangsu province. The study were divided into three groups: (1) Three different doses of enalaprilat (1.25mg, 2.5mg, 5mg)were injected by an intravenous bolus to 10 cases for each group to evaluate the appropriate dosage. (2) A comparison of enalaprilat (2.5mg iv )and phentolamin (5mg iv )in 54 for each group of severe hypertension. (3) The antihypertensive effect of continuous bolus injection of enalaprilat every 6 hours to 34 cases in 24 hours. Results (1) The bolus of 2.5 mg enalaprilat is the most appropriate dosage to decrease the severe hypertension. (2) After 1-24 hours,the blood pressure decreased significantly in both enalaprilat and phentolamin injection groups (P<0.05), more reductions of systolic blood pressure and distolic blood pressure were s[1] [2] 下一页
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