|
抗Sa抗体的检测及其临床意义 |
| |
程秀峰 曾庆馀 陈肃标 谢素和 许杰州 肖征宇 黄少弼
【摘 要】 目的 了解抗Sa抗体的临床意义。方法 从新鲜人胎盘中提取Sa抗原，应用免疫印迹法检测类风湿关节炎(RA)及其他风湿病患者血清的抗Sa抗体，结合临床资料进行分析。结果 192例RA中抗Sa抗体阳性65例，对RA诊断的敏感性为33.9%，特异性为96.9%。其中同时出现相对分子量为50 000、55 000两条带的15例(23.1%)，其医师和患者对病情活动性的评价、患者对关节痛的评价及C反应蛋白(CRP)增高与单独出现50 000条带者相比，均显著增高。31例早期RA抗Sa抗体阳性率为32.3%，9例经随访确诊RA者4例抗Sa抗体阳性；63例RF阴性RA中抗Sa抗体阳性率为27%。抗Sa抗体阳性组以小关节起病为主，且RF滴度明显较阴性组高。结论 抗Sa抗体有助于早期RA和RF阴性RA诊断，同时出现50 000、55 000两条带可能与病情活动有关。
【关键词】 关节炎，类风湿； 抗Sa抗体； 临床意义
Anti-Sa antibody in rheumatoid arthritis
CHENG Xiufeng,ZENG Qingyu,CHEN Subiao,et al.
Department of Rheumatology,Shantou University Medical College,Shantou 515031,China
【Abstract】 Objective To investigate the significance of anti Sa antibody in rheumatoid arthritis (RA).Methods Sa antigen was extracted from human fresh placenta.Anti-Sa antibody was detected at the sera titer of 1∶40 using Western blotting,and its clinical significance was investigated with the corresponding clinical materials.Results Anti-Sa antibody was found in 33.9% (65/192) of RA patients.Its specificity for RA was 96.9%.The scores of patient′s and physician′s global assessment of disease activity,patient′s assessment of pain and level of C-reaction protein were higher in anti-Sa antibody existed with 50 000 and 55 000 bands than that in anti-Sa antibody with single 50 000 band.Anti-Sa antibody was detected in 32.3% (10/31) of early RA patients and in 27% (17/63) of RF negative RA patients.Anti-Sa antibody was also found in 4 of 9 RA patients at the time when the diagnosis could not be established.The titers of RF in the anti-Sa positive RA patients were higher than the negative ones.Conclusion Anti-Sa antibody is a valuable diagnostic parameter for RA,especially in early RA and RF negative RA. Anti-Sa antibody with both 50 000 and 55 000 bands could be related to disease activity.
【Key words】 Arthritis,rheumatoid; Anti-Sa antibody; Clinical significance
[1] [2] 下一页
上一个医学论文： T细胞免疫核糖核酸治疗大鼠佐剂关节炎的研究
下一个医学论文： 强直性脊柱炎患者外周血单个核细胞HLA
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文