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空腹甘油三酯水平正常的2型糖尿病患者脂肪餐负荷试验的临床研究 |
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傅晓英 张菱 鲁平 汪新宇 李全中 文世林 董义光
【摘要】 目的 研究空腹甘油三酯水平(TG)正常的2型糖尿病患者餐后脂代谢的改变。方法采用改良脂肪餐负荷试验对33例空腹TG正常(观察组)和10例空腹TG增高(高脂组)的2型糖尿病患者以及10名健康对照者(对照组)进行餐后脂代谢研究。前者依据餐后4小时TG(TG4h)再分为餐后正常组和餐后增高组。结果 脂餐后受试者2～8小时TG水平均有所增高，高密度脂蛋白-胆固醇(HDL-C)都有一个轻微的低谷改变，其中观察组较对照组TG4h的增高和4小时HDL-C的降低差异有显著性(P＜0.05)；餐后总胆固醇(TC)变化均不明显，组间各时段比较差异无显著性(P＞0.05)。餐后TG峰值，TG曲线下面积(TG-AUC)和TG峰值时间按对照组、餐后正常组、餐后增高组和空腹增高组的次序依次递增(前两组比较和后两组比较均为P＞0.05)。结论 部分空腹TG水平正常的糖尿病患者存在餐后TG水平的增高、廓清延迟和HDL-C降低，其程度与空腹高TG血症者基本相当。
【关键词】 糖尿病，非胰岛素依赖型； 甘油三酯类； 脂肪餐负荷试验
Clinical study on oral fat-load test in fasting normotriglyceridemic type 2 diabetic patients
FU Xiao-ying ZHANG Ling LU Ping et al
（Department of Endocrinology, Henan Province People's Hospital,Zhengzhou 450003）
【Abstract】 Objective To study the change of postprandial lipid metabolism in fasting normotriglyceridemic type 2 diabetic patients. Methods Subjects were assigned to three groups: the observed group of 33 fasting normotriglyceridemic type 2 diabetic patients who were divided into two subgroups: subgroup 1 〔4 hour postprandial blood triglyceride level (TG4h≤2.0mmol/L)〕 and subgroup 2 (TG4h＞2.0mmol/L) according to the level of TG4h+2s in control group; the healthy control group of 10 normal subjects and the diabetic control group of 10 fasting hypertriglyceridemic type 2 diabetic patients (hyper-TG groups). Total cholesterol (TC), HDL-cholesterol (HDL-C), and total triglyceride (TG) were measured before and 2, 4, 6 and 8 hours after a fatty test meal (600 kcal, 45% carbohydrate, 35% fat and 20% protein). Results 2～8 hours after the test meal, a slightly postprandial increase of TG and a slightly postprandial decrease of HDL-C were observed, and there was a significant differences in TG4h and HDL-C4h between the observed group and healthy controls (P＜0.05). Postprandial change in mean TC was slight and without significant differences between the two groups. Following the order of the control grou[1] [2] 下一页
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