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绝经后女性冠心病患者血脂变化特点 |
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汪芳 李健斋 褚德发 何青 王抒 杨杰孚 许峰 孙福成 季福绥 满咏
【摘要】 目的 观察绝经后女性冠心病(CHD)患者血脂变化特点，以比较各血脂指标与CHD患病之间的关系。方法 选择经冠状动脉造影证实(冠状动脉狭窄≥50%)的女性CHD患者101例，年龄（63.7±7.1）岁；并以与其体重指数、高血压及吸烟等病史相匹配的101例健康女性相对照，年龄（61.5±6.8）岁。观察各项血脂指标在两组间变化特点及其相互关系。结果 (1)与对照组比较，CHD患者的血清LDL-C［(3.38±0.88) mmol/L比（2.91±0.91)mmol/L］、Lp(a)［(217±176)mg/L比（152±118）mg/L］及TG［(1.80±0.99) mmol/L比（1.40±0.95）mmol/L］水平较高；而apo AI［(1.25±0.21)g/L比（1.40±0.18)g/L］和HDL-C［(1.20±0.31) mmol/L比（1.46±0.36) mmo/L］水平明显下降(P值均＜0.01～0.001)并且以apo AI改变更明显。(2)多元逐步回归优选的判断指标是apo AI(P=0.0001)，Lp(a)(P=0.002)及LDL-C(P=0.0061)。结论 绝经后女性CHD血脂特点，主要为HDL降低及Lp(a)偏高，与TC偏低的老年男性CHD相似。
【关键词】 冠状动脉疾病 妇女 绝经后期 脂类
The changes of lipid levels in postmenopause female patients with coronary heart disease WANG Fang, LI Jianzhai, CHU Defa, et al. Department of Cardiology, Beijing Hospital, Beijing 100730
【Abstract】 Objective The purpose of this study is to investigate the lipids profile of patients with coronary heart disease (CHD) in postmenopause females, and the relationship of those lipid parameters with CHD. Methods 101 postmenopause female CHD, documented by angiography, were selected as CHD group, 101 normal female subjects as control, whose body weight index, the history of smoking and/or hypertension, matched with CHD group. Results （1） The serum levels of low-density lipoprotein cholesterol (LDL-C), lipoprotein (a) ［Lp(a)］ and triglyceride (TG) were higher in CHD group than that in control; while the levels of apolipoprotein AⅠ(apoAⅠ) and high-density lipoprotein cholesterol (HDL-C) were much lower in CHD group than that in control (P<0.01-0.001). (2) Multi-varietic regression analysis showed that there were closer relationships between female CHD and decrease in apoAI, as well as increase in Lp(a) or LDL-C. Conclusion Decrease in HDL and increase in Lp(a) were the main changes of lipid profile in postmenopause CHD pat[1] [2] [3] 下一页
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