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肾综合征出血热患者血清IL |
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Serum interleukin (IL)-6, urine tumor necrosis factor, IL-6 and IL-8
levels in patients with hemorrhagic fever with renal syndrome
樊万虎 岳金声 刘正稳 张帆 张成文
Fan Wanhu, Yue Jinsheng, Liu Zhengwen, et al
【摘要】 目的 探讨细胞因子在肾综合征出血热(HFRS)发病中的作用。方法
采用双抗体夹心ELISA法对48例HFRS患者及20例正常人血清白细胞介素(IL)-6、
尿液肿瘤坏死因子(TNF)、IL-6、IL-8进行动态检测。结果 HFRS患者血清IL-6、
尿液TNF、IL-6、IL-8含量较对照组明显增高(P＜0.001)；发热期已增高，低血压
期继续增高，少尿期达峰值；其含量随病情加重而升高，各型间差异有显著性；
血清IL-6与特异性抗体升高有明显关系，与血清β2-微球蛋白(β2-MG)、血尿素氮
(BUN)、血肌酐(Cr)均呈高度正相关；尿液IL-6与TNF、IL-8呈显著正相关(r=0.5621，
P＜0.005；r=0.3845，P＜0.01)。结论 HFRS患者病程中TNF、IL-6、IL-8均处于高
活性状态，IL-6与体液免疫反应亢进所致的免疫病理损伤有关，IL-6、IL-8、TNF参
与肾脏的免疫损伤，可作为判定患者预后和转归的指标。
【关键词】 肾综合征性出血热 白细胞介素类 肿瘤坏死因子
Serum interleukin (IL)-6, urine tumor necrosis factor, IL-6 and IL-8 levels
in patients with hemorrhagic fever with renal syndrome Fan Wanhu, Yue
Jinsheng, Liu Zhengwen, et al. Department of Infectious Disease, First Teaching Hospital,
Xi an Medical University, Xi an 710061
【Abstract】 Objective To explore the role of cellular factors in the pathogenesis
of hemorrhagic fever with renal syndrome (HFRS). Methods Double antibody sandwich
ELISA was used to determine serum interleukin (IL)-6, urine tumor necrosis factor (TNF),
IL-6 and IL-8 levels from 48 patients with HFRS. Results Serum IL-6, urine TNF, IL-6
and IL-8 concentrations in HFRS patients were significantly higher than in controls (P?.001),
and those in HFRS patients increased at fever stage, then continued to increase during hypotension
stage and peaked at oliguria stage. The concentrations of serum IL-6, urine TNF, IL-6 and IL-8
increased in accord with the severities of the disease and differred greatly among different types
of the disease. Serum IL-6 levels have remarkable relationships with the serum specific antibodies,
and it was positively related[1] [2] [3] 下一页
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