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重型乙型肝炎肝内细胞间粘附分子 |
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张绪清 顾长海 张瑞 王宇明
【摘要】目的 探讨细胞间粘附分子-1(ICAM-1) mRNA在重型乙型肝炎肝内的表达水平及其意义。方法 用原位杂交技术检测11例非肝病对照者，5例慢性无症状HBsAg携带者(AsC)、15例慢性乙型 肝炎和30例重型乙型肝炎患者肝内ICAM-1 mRNA原位表达。结果 非肝病者和AsC肝细胞无ICAM-1 mRNA表达；重型乙型肝炎患者肝细胞ICAM-1 mRNA表达明 显增强，其表达水平显著高于慢性乙型肝炎。结论 ICAM-1在重型乙型肝炎肝坏死中起重要作用。
【关键词】细胞间粘附分子-1；乙型肝炎
Hepatic expression of intercellular adhesion molecule-1 mRN A in severe viral hepatitis B
ZHANG Xuqing GU Changhai ZHANG Rui et al.
(Department of Infectious Diseases, Southwest Hospital,The Third Military Medical University, Chongqing 400038,China)
【Abstract】Objective To study hepatic expression of intercellular adhesion molecule-1 (ICAM-1) mRNA and its role in the pathogenesis of severe viral hepatitis B. Methods Hepatic expression of ICMA-1 mRNA was studied in 11 individuals without liver d iseases, 5 chronic asymptomatic HBsAg carriers (AsC), 15 patients with chronic h epatitis B and 30 patients with severe hepatitis B by in situ hybridization. Results No ICAM-1 mRNA expression was found in the hepatocytes on the specimens from in dividuals without liver diseases and AsC. Enhanced expression of ICAM-1 mRNA was observe d on the hepatocytes in the patients with severe hepatitis B, and it was stronge r than that in the patients with chronic hepatitis B. Conclusion IC AM-1 plays an important role in the mechanism respons ible for liver necrosis in the patients with severe viral hepatitis B.
【Key words】Intercellular adhesion molecule-1; H epatitis B
细胞间粘附分子-1(intercellular adhesion molecule-1, ICAM-1)属免疫球蛋白 超家 族成员，其配体是淋巴细胞功能相关抗原-1(lymphocyte function associated antigen- 1,LFA-1)［1］。近年研究表明ICAM-1/LFA-1介导的细胞粘附在慢性乙型肝炎免疫 发病机制中起重要作用［2］，但有关重型乙型肝炎肝内ICAM-1表达的研究较少。我 们旨在探讨重型乙型肝炎患者肝内ICAM-1 mRNA表达水平及其意义。
材料与方法
一、对象
50例乙型肝炎病毒(HBV)感染者均为我院1996～1998年的住院患者，男41例，女9例，平均年 龄34.6岁，其中 慢性无症状HBsAg携带者(AsC)5例、轻度慢性肝炎15例、急性重型肝炎2例、亚急性重 型肝炎6例、慢性重型肝炎22例，诊断均符合1995年全国传染病与寄生虫病学 术会议修订的病毒性肝炎防治方案的标准。对照组11例均为意[1] [2] 下一页
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