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帕金森病猴模型纹状体多巴胺转运蛋白和多巴胺D2受体显像的比较研究 |
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;were imaged by autoradiography with 131I-IBZM. The levels of dopamine (DA) and its metabolites were measured by high performance liquid chromatography and electrochemical detection (HPLC-ECD). The histopathology was observed by microscopy and hematoxylin and eosin(HE) stain.Results The reduced uptake of 99mTc-TRODAT-1 in MPTP-lesioned striatum was found by SPECT, as compared with that in intact one, but no difference of 131I-IBZM, 131I-AIBZM uptake was noted between the bilateral striata. The finding of autoradiography was in accordance with that of SPECT scanning with 131I-IBZM and 131I-IBZM. The neurochemical and neuropathological changes in hemiparkinsonian monkey model paralleled that of SPECT imaging with 99mTc-TRODAT-1.Conclusion The change of DAT is earlier than that of D2R in the hemiparkinsonian monkey model with no APO-induced rotational behavior. The SPECT imaging of striatal DAT is helpful for the early diagnosis of PD and for monitoring the progression of the disease.
【Key words】 Parkinson disease;Carrier proteins;Receptors, dopamine D2; Tomography, emission-computedSingle-photon
帕金森病（Parkinson disease,PD）的特征性病理改变是中脑黑质多巴胺(DA)能神经元变性，受其支配的纹状体DA含量显著降低，产生运动减少、肌僵直、震颤、姿势障碍等临床症状。由于黑质DA能神经元变性，纹状体部位的突触前膜多巴胺转运蛋白（dopamine transporter, DAT)上一页 [1] [2] [3] [4] [5] [6] 下一页
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