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浅论曲美他嗪治疗老年不稳定型心绞痛的临床研究 |
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eeks treatment, the angina attack frequency and the nitroglycerin daily consumption of the observation group were reduced significantly and the levels of LVEF and LVFS increased significantly. There were significant difference between the observation group and the control group (P<0.05). However, there were no significant changes in the heart rate, the blood pressure and the production of the heart rate and blood pressure after the treatment in two groups. Conclusions Trimetazidine have antiischemic effect and can play the direct protective role on myocardial cells, without effects in changing hemodynamic and heart rate or blood pressure.It is a good choice to cure the UA in the coronary heart disease.
【Key words】 unstable angina; trimetazidine; aged
不稳定型心绞痛(UA)是临床上常见的冠心病类型,以往的抗心绞痛治疗主要用药为硝酸酯类、钙通道拮抗剂及β受体阻滞剂,以及抗凝、抗栓治疗,本研究在常规治疗心绞痛的基础上,联合曲美他嗪治疗老年UA,以探讨治疗老年UA更有效的方法。
1 资料与方法
1.1 临床资料 从2007年8月至2008年7月在我院住院的老年UA患者80例,根据1979年WHO制定的缺血性心脏病的命名与诊断标准,均符合UA的诊断,并排除急性心肌梗死、出血性疾病、重度心力衰竭、心源性休克、严重肝肾功能不全者,按入院顺序编号随机分组,单数为观察组,双数为对照组。其中初发型心绞痛8例,恶化型心绞痛37例,自发性心绞痛19例,混合性心绞痛16例。观察组40例,男31例,女9例,年龄65~86岁,平均(73.2±6.7)岁,病程(11.6±4.8)年;对照组40例,男30例,女10例,年龄63~85岁,平均(72.6±6.8)岁,病程(12.8±4.5)年。2组间年龄、性别及患高血压、糖尿病等并发症情况比较,差异无显著性(P>0.05);2组主要临床症状、UA发作频率、心电图ST段及T波改变比较,差异无显著性(P>0.05);具有可比性。
1.2 方法 所有患者均给予常规治疗(如低分子肝素、硝酸酯类药物、β受体阻滞剂、阿司匹林、钙通道拮抗剂、血管紧张素转换酶抑制剂及调脂药物),在此基础上,观察组加用盐酸曲美他嗪,上一页 [1] [2] [3] [4] [5] 下一页 上一个医学论文: 对中老年2型糖尿病患者抑郁焦虑状况调查 下一个医学论文: 第12届感染性疾病国际会议 12th ICID 报道
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