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浅论曲美他嗪治疗老年不稳定型心绞痛的临床研究 |
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【摘要】 目的 观察在常规治疗基础上，联合曲美他嗪治疗老年不稳定型心绞痛的疗效。 方法 将80例老年不稳定型心绞痛患者，按入院顺序编号分组，单数归入观察组,接受常规治疗联合曲美他嗪,双数归入对照组,只接受常规治疗。观察2组治疗前后心绞痛发作次数、每日硝酸甘油用量、疗效，记录左室射血分数、左室短轴缩短率等，并对2组进行比较。 结果 治疗12周后，与对照组比较，观察组在心绞痛发作频率上明显减少，硝酸甘油用量减少，左室射血分数增加及左室短轴缩短率增加，疗效更显著(P<0.05)。而治疗前后2组心率、血压及心率与血压的乘积均无明显变化。 结论 曲美他嗪具有抗缺血作用，直接对心肌细胞提供保护，但不影响血流动力学改变，也不降低心率、血压，是治疗冠心病不稳定型心绞痛的良好选择。
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【关键词】 不稳定型心绞痛; 曲美他嗪; 老年人
Effect of trimetazidine on unstable angina in elderly patients XIAO Li，HU Liangzi. Department of Cadre, the Affiliated Hospital of Wuhan University of Science and Technology, Wuhan 430064,China
【Abstract】 Objective To explore the therapeutic effect of trimetazidine on unstable angina(UA) in elderly patients receiving conventional therapy. Methods Eighty elderly cases of UA were selected and divided into two groups according to the admission number (AD) at random. The patients with an odd AD were enrolled into observation group (receiving trimetazidine combined with routine treatment), while the patients with an even AD enrolled into the control group (receiving routine treatment). The angina attack frequency, left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were compared between these two groups before and after treatment. Results After 12 w[1] [2] [3] [4] [5] 下一页
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