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论连翘醇提物对恶性胸腹水中原代肿瘤细胞的抗肿瘤作用 |
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;and pleural fluids of 25 patients. Compared with culture cell lines, the response of these cancer cells to EEFF and chemotherapeutic agents commonly used were determined by CCK8 assay. Quantitative RTPCR was used to examine the role of EEFF in the expression of apoptosisrelated gene including Survivin and Bcl2. Results The average 50% inhibiting concentration (IC50 )of EEFF against the 4 cell lines was 191.88 μg/ml. The primary cancer cells isolated from effusions showed sensitivity to EEFF with IC50 values of 406.13 μg/ml， which showed no significant difference compared with the primary cell lines(P>0.05). The antitumor effect of EEFF was not influenced by the origin of the fluids(P>0.05). IC50 of EEFF against the primary cells from patients treated with chemotherapy was 543.13 μg/ml, which was significantly higher than that without chemotherapy. Age, gender, and origin of fluids didnt influence IC50 significantly. Cancer cells isolated from effusions of 7 patients were resistant to EEFF, which also had increased tolerance to docetaxel, cisplatin and 5fluorouracil. The primary cells resistant to chemotherapeutics didnt 上一页 [1] [2] [3] [4] [5] [6] [7] 下一页
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