|
自发性脑出血患者血清MMP 9及TIMP 1水平的研究 |
| |
【摘要】 目的 研究自发性脑出血患者血清基质金属蛋白酶_9(MMP_9)及其抑制因子基质金属蛋白酶抑制因子_1(TIMP_1)的含量及临床意义。方法 采用酶联免疫吸附法对62例48小时内入院的脑出血患者血清MMP_9和TIMP_1水平进行测定，与正常对照组进行比较，同时用免疫比浊法测高敏C_反应蛋白(hs_CRP)水平，并与CT所示血肿周围水肿体积和神经功能评分进行相关分析。结果 脑出血患者血清MMP_9及TIMP_1水平较正常对照组明显升高(P＜0.01)，脑出血组MMP_9的含量与CT所示出血灶周围水肿区体积呈显著正相关(r=0.627，P＜0.01)。结论 脑出血患者血清MMP_9及TIMP_1水平明显增高，血清MMP_9可能成为早期反映脑出血患者血肿周围水肿严重程度和预后的指标。
【关键词】 脑出血;基质金属蛋白酶_9;组织抑制因子_1;脑水肿
Study on Matrix Metalloproteinase_9（MMP_9） and Tissue Inhibitor of Matrixmetalloproteinase_1（TIMP_1） in Patients with Spontaneous Intracerebral Hemorrhage. ZHOU Yuan_lin, KE Sao_fa, ZHANG Dan_hong, et al. Department of neurology, Taizhou Hospital, Zhejian 17000,China
［Abstract］ Objective To observe serum MMP_9 and TIMP_1 levels in patients with spontaneous intracerebral hemorrhage (ICH) and explore its clinical significance. Methods Serum MMP_9 and TIMP_1 were determined by enzyme_linked immunosorbent assay（ELISA） in 62 ICH patients hospitalized within 48h and 68 healthy people（control）. C_reactive protein was determined by immunoturbidimetry. The relationship between serum MMP_9 and the perihematomal edema(PHE) volume measured by cranial CT scan and neurological assessment was investigated. Results Serum levels of MMP_9 and TIMP_1 were higher in ICH patients than those in healthy people (P＜0.01). Serum MMP_9&nb[1] [2] [3] [4] [5] 下一页
上一个医学论文： 血小板源性生长因子受体基因重排的研究
下一个医学论文： 高血压脑出血手术治疗的临床研究
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文