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过敏性紫癜患儿静脉血ICAM |
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张克军 李聪敏 姜天云 赵嘉惠 安小敏 王莲芸 乔中东
【摘 要】 目的 探讨全身血管炎症性疾患—过敏性紫癜细胞间粘附分子-1(ICAM-1)的表达意义。方法 采用半定量反转录聚合酶链反应测定了13例患儿 及5名健康儿静脉血白细胞中ICAM-1表达。结果 12例患儿呈阳 性表达(92.31%)，4名健康儿呈阴性表达；患儿中6例有肾脏损害(46.15%)，其中5例ICAM -1表达阳性。经秩和检验，患儿组与对照组间有明显差异(P＜0.005)。结 论 ICAM-1是全身性血管炎及内皮损伤的一个标志；ICAM-1阳性表达可能提示 过敏性紫癜处于活动期；在活动性紫癜性肾炎中，ICAM-1表达可明显增加。
【关键词】 紫癜，过敏性 细胞粘附分子 血管炎 儿童
Significance of expression of ICAM-1 in blood on Henoch-Schoenlein pu rpura
ZHANG Kejun,LI Congmin,JIANG Tianyun,et al.First Hospital,Shanx i Medical University, Taiyuan 030001
【Abstract】 Objective To investigate the sign ificance of expression of intracellular adhesion molecules 1 (ICAM-1) on Henoch -Schoenlein purpura,one of the systemic vasculitis.Methods Thi rteen children with Henoch-Schoenlein purpura and 5 healthy children as the con trol were enrolled in this study.ICAM-1 in their blood was detected by semi-qu antity reverse-transcription polymerase chain reaction (RT-PCR).Result s ICAM-1 in 12 sick children were positive (92.31%),and 4 healthy wer e negative transcripted.Six of 13 sick children suffered from renal damage (46. 15%),in which ICAM-1 in 5 cases was positive.The rank-tesk result between the two groups′PCR-products in amount revealed that there was a significant differ ence (P＜0.005).Conclusion ICAM-1 is one of the markers o f systemic and vascular inflammation and endothelial damage.The positive express ion of ICAM-1 suggests that the purpura may be in active phase,and ICAM-1 in t he active phase of purpura nephritis could be obviously increased.
【Key words】 Purpura,Schoenlein-Henoch Adhesion molecules Vasculitis Child
过敏性紫癜是儿童时期最为常见的以小血管炎症为主要病变的变态反应性疾病，又称白细胞 碎裂性血管炎［1］，病因不明。已发现在川崎病、系统性红斑狼疮等血管炎症性患 者的循环白细胞中细胞间粘附分子-1(ICAM-1)的浓度可以增加［2］。ICAM-1在炎 症过程中起着重要的作用，本研究目的在于探讨过敏性紫癜患儿静脉血白细胞ICAM-1浓度 与正常健康儿相比是否增高。
1 材料与方法
1.1 一般资料
1996年10月—1997年10月我院儿科收治的过敏性紫癜患儿13例，据实[1] [2] 下一页
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