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比索洛尔 拉西地平和赖诺普利对高血压病患者24小时血压的影响 |
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The efficacy of once-daily bisoprolol, lacidipine and lis
inopril on 24-hour blood pressure in patients with essential hypertension
朱理敏 王宪衍 金翠燕 钱珠
Zhu Limin, Wang Xianyan, Jin Cuiyan, et al
【摘要】 目的 比较比索洛尔、拉西地平和赖诺普利对29例高血压病患者的降
压疗效。方法 采用随机、单盲和交叉的方法，运用24小时动态血压监测。结果
三药均能显著降低血压，彼此间降低偶测血压的幅度无显著差异。比索洛尔和拉
西地平降低24小时平均和白天平均血压的幅度大于赖诺普利。三药均能有效控制
清晨血压高峰期的血压，它们的降压谷/峰比值都超过65%。结论 比索洛尔、拉
西地平和赖诺普利均可每日服用1次，前二药控制24小时血压及清晨醒后的高峰期
血压较后者为佳。
【关键词】 高血压 血压监测，便携式 比索洛尔 拉西地平 赖诺普利
The efficacy of once-daily bisoprolol, lacidipine and lisinopril on 24-hour blood pressure
in patients with essential hypertension Zhu Limin, Wang Xianyan, Jin Cuiyan, et al. Rui Jin
Hospital, Shanghai Institute of Hypertension, Shanghai Second Medical University, Shanghai 200025
【Abstract】 Objective To compare the antihypertensive effects of bisoprolol, lacidipine and
losinopril in 29 patients with essential hypertension. Methods A randomized, single-blind and crossover
study was performed and blood pressure was measured by 24-hour ambulatory blood pressure monitoring.
Results Bisoprolol, lacidipine and lisinopril significantly reduced both systolic and diastolic casual
blood pressures when compared with placebo and no differences were observed among these three
drugs. Bisoprolol and lacidipine had greater reduction of 24h mean and daytime mean ambulatory blood
pressures than that of lisinopril. The rapid rise in blood pressure in the morning hours was well controlled
by all the three drugs, however, bisoprolol and lacidipine were better than lisinopril. The trough to peak
ratios of systolic and diastolic blood pressures of the three drugs were all above 65%. Conclusion
Bisoprolol, lacidipine and lisinopril used once daily could control 24h blood pressure effectively in
patients of essential hypertension, but bisoprolol and lacidipine are be[1] [2] 下一页
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