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中国儿童1型糖尿病发病率的研究 |
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王克安 李天麟 李新华 杨泽 魏一大 颜纯 刘尊永 倪桂臣 金书香
陈泓 秦汝莉 李彦琴 李玉瑞 Janice S. Dorman Ronald E. LaPorte
【摘要】 目的 研究我国儿童1型糖尿病的发病率。方法 中国预防医学科学院WHO DiaMond项目中国协调中心在全国建立了登记网络。16个省、市和自治区的20个地区根据该中心的计划和要求，对1988～1996年期间诊断的＜15岁的1型糖尿病病例进行了回顾性的登记。该研究覆盖＜15岁儿童1 900余万，登记到我国九个民族，共发现883例1型糖尿病病人。结果 显示该时期总的确定校正发病率为0.59/10万人年〔95%可信区间(CI)：0.57～0.60〕，其中男0.52/10万人年(95% CI：0.50～0.54)，女0.66/10万人年(95% CI：0.64～0.68)。按1990年全国人口构成比例标化的确定校正发病率为0.57/10万人年。结论 我国儿童1型糖尿病的发病率在逐年上升；发病率随年龄的增长而增加；民族间的发病率差异达12倍；发病率在不同地区之间呈现明显的南低北高现象。
【关键词】 糖尿病，1型 流行病学 发病率
Incidence of childhood type 1 diabetes mellitus in China
WANG Kean,LI Tianling,LI Xinhua,et al.WHO DiaMond Project China Coordinating Center,Chinese Academy of Preventive Medicine,Beijing,100050
【Abstract】 Objective To investigate into the incidence rate (IR) of childhood type 1 diabetes mellitus in China. Methods A nationwide register network was established by the WHO DiaMond Project ChinaCoordinatingCenter,Chinese Academy of Preventive Medicine (CAPM). Coordinated by that center and following the standardized protocol, 20 local centers in 16 provinces, autonomous regions and municipalities of China registered retrospectively the newly diagnosed cases of type 1 diabetes mellitus with onset age＜15 years between 1988～1996. Results The population under investigation was more than 19 million, and 883 type 1 diabetes mellitus from 9 nationalities were registered. The overall ascertained and corrected type 1 diabetes IR was 0.59 per 100000 person-year. The gender specific IRs were 0.52/100000 (95% CI: 0.50～0.54) for males and 0.66/100000 (95% CI:0.64～0.68) for females. The standard ascertained and corrected IR according to the national age-specific population in 1990 was 0.57 per 100000 person-year, which was the lowest rate ever reported by other countries. Conclusions The IRs of childhood type 1 diabetes mellitus in China were increasing with passage of time; the age-specific IRs [1] [2] 下一页
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