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中国人血清瘦素水平与肥胖度的关系 |
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顾卫琼 陈名道 唐金凤 李凤英 陈春荣 罗敏 陈家伦 许曼音
【摘要】 目的 研究15～68岁中国人血清瘦素(leptin)水平与体脂、年龄、性别及睾酮的关系。方法 用放射免疫分析法测定77例正常非肥胖和28例超重或肥胖个体〔体重指数(BMI)≥25〕的血清瘦素水平。结果 中 国人正常非肥胖者 平均瘦素浓度男性为(2.15±1.46)μg/L，女性为(7.86±3.60)μg/L；超重或肥胖者平均瘦素浓度男性为(4.87±3.47)μg/L，女性为(16.59±6.92)μg/L，女性均较男性高约2～3倍。血清瘦素水平与BMI显著相关(男子r=0.69,P＜0.001；女子r=0.63,P＜0.001)，但25%的肥胖个体仍存在有瘦素的相对性缺乏。结论 血清瘦素水平与BMI显著相关提示多数肥胖个体存在瘦素抵抗，部分瘦素相对性缺乏的肥胖者将有可能成为瘦素治疗的对象。
【关键词】 瘦素 肥胖 体重指数
The relationship between serum leptin concentration and adiposity in Chinese
GU Weiqiong,CHEN Mingdao,TANG Jinfeng,et al.
Shanghai Institute of Endocrinology,Rui Jin Hospital,affiliated to Shanghai Second Medical University,200025
【Abstract】 Objective To investigate the relationship between serum leptin concentration and body fat, gender, age and testosterone in Chinese. Methods The serum leptin concentrations were measured in 77 lean and 28 overweight or obese 〔body mass index (BMI)≥25〕 subjects by RIA. Results The serum leptin concentrations in lean Chinese were (2.15±1.46)μg/L in male and (7.86±3.60)μg/L in female, while in overweight or obese ones they were (4.87±3.47)μg/L in male and (16.59±6.92)μg/L in female, which were 2～3 times higher in women than in men. In both men and women, in spite of a relative deficiency of leptin in 25% of obese persons, fast leptin levels were significantly correlated with BMI (r=0.69, P＜0.001 in male and r=0.63, P＜0.001 in female). Conclusion Serum leptin concentrations are correlated with BMI, suggesting that most obese persons are resistant to leptin. Those who are relatively deficient of leptin may become the good candidates for leptin treatment in the future.
【Key words】 Leptin Obesity Body mass index
(Chin J Endocrinol Metab, 1999,15：15-18)
肥胖(ob)基因的蛋白产物瘦素(leptin)是一种相对分子质量约为16000的脂肪组织源激素。瘦素作为脂肪组织和中枢神经系统间网络联系的外周信号，可能通过血脑屏障[1] [2] 下一页
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