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普罗帕酮 莫雷西嗪 美西律的疗效和安全性再评价 |
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ase, hypertension, and unknown cause groups. The initial dose was 300 mg/day for any drug. The dosage was titrated later on but not more than 1200 mg/day. Patients with treatment failure with one drug was switched randomly to another drug. Arrhythmias were assessed by Holter monitoring. The duration of follow-up was 6-48(28.3±8) months.Results (1) The effective rates for ventricular arrhythmias in patients given propafenone (n=337), moricizine (n=246), mexiletine (n=229) and placebo (n=112) were 66.8%, 72.7%, 64.2% and 20.5%, respectively. The effective rates for supraventricular arrhythmias in patients given propafenone (n=271),moricizine (n=144) and placebo(n=64) were 71.2%, 60.4% and 23.4%, respectively. The difference was significant (P<0.001) between any drug group and placebo group but insignificant (P>0.05) between any two drug groups; (2) No difference in effective rate was noted among groups of different etiology or duration of arrhythmias; (3) The optimal dosage was 400-800 mg/day for any drug ; (4) There was no definite relationship between blood drug concentration and the efficacy of treatment with each of the 3 drugs; (5) The occurrence rates of adverse reactions were 17.7%, 36.6%, 35.5% and 5.3% for propafenone, moricizine, mexiletine and placebo, respectively, in which cardiovascular reactions accounted for 28.4%, 17.5% and 4.8% in the three-drug treatment groups. No significant difference in the occurrence rate of adverse reactions was found among different drug treatment groups; (6) There were more cardiac adverse reactions in the propafenone group and morcizine group than those in mexiletine. Increase of VPCs occurred in 2 cases treated with propafenone, and paroxysms of VT increased in 1 case treated with mexiletine. The only one death was due to left heart failure in the moricizine group. There were more adverse reaction of gastrointestinal tract in mexiletine group and moricizine group than those in propafenone, and more side-effec 上一页 [1] [2] [3] 下一页
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