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甲状腺疾病时甲状腺组织性激素受体的免疫组织化学研究 |
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卢桂芝 高燕明 高妍 唐素恩
【摘要】 目的 了解性激素及其受体在甲状腺疾病发病中的作用。方法 用免疫组化ABC法研究了不同甲状腺疾病时甲状腺组织中的性激素受体(AR、ER和PR)。结果 在正常甲状腺组织中有少量的性激素受体表达，但阳性率不高；甲状腺癌组织中性激素受体的表达明显增加，尤其在乳头状腺癌组织中AR、PR 增加更明显，不仅高于正常人也高于腺瘤和结节性甲状腺肿(P＜0.01，0.01，0.05)；腺瘤和结节性甲状腺肿的ER明显高于正常人(P＜0.01)；桥本甲状腺炎三种性激素受体的阳性率也高于正常人，但无统计学差异。结论 虽然各种甲状腺疾病均多发于女性，但它们与性激素受体的关系不一样，甲状腺癌可能与雄激素及孕激素的作用增强有关，而良性甲状腺疾病与雌激素作用关系更密切。
【关键词】 甲状腺疾病 免疫组织化学 雌激素受体 孕激素受体 雄激素受体
Immunohistochemical study on sex hormone receptors in thyroid diseases
LU Guizhi,GAO Yanming,GAO Yan,et al.Department of Endocrinology,First Teaching Hospital of Beijing Medical University,Beijing,100034
【Abstract】 Objective To clarify the effects of sex hormones and their receptors on disease of the thyroid. Methods Sex hormone receptors (AR,ER and PR) in thyroid tissue from different thyroid diseases were studied by ABC immunohistochemical method. Results There was little sex hormone receptor expression in normal thyroid tissue with low positive rate. The positive rates of three sex hormone receptors in thyroid carcinomas were significantly high. The positive rates of AR and PR were higher in papillary carcinoma than in normal thyroid, nodular goiter as well as in adenoma tissue (P＜0.01, 0.01＜P＜0.05). The positive rate of ER was higher in adenoma and nodular goiter than in normal thyroid tissue (P＜0.01). The positive rates of three sex hormone receptors were higher in Hashimoto s thyroiditis than in normal thyroid tissue, but without statistical significance. Conclusion Thyroid carcinoma may relate with the action of androgen and progesterone, while other thyroid diseases may relate with the action of estrogen.
【Key words】 Thyroid disease Immunohistochemistry Estrogen receptor Progesterone receptor Androgen receptor
Chin J Endocrinol Metab, 1999,15：82-85)
临床上各种甲状腺疾病的发病率女性均高于男性，这种性别的差异可能与性激素的作用有关。而性激素对组织的作用是通过其受体，因此，甲状腺组织中性激素受体的研究成为人们关心的问题。八十年代用生物化学方法已经证明在甲状腺组织中存在雄激素受体(AR)、雌[1] [2] 下一页
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