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血清肌钙蛋白与结缔组织疾病损伤心脏的相关研究 |
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李瑾 肖传实 王来远 梁树芬 王彩虹 周华 边云飞
【摘 要】 目的 探讨血清肌钙蛋白I(troponin I，Tn-I)、肌钙蛋白T(troponin T,Tn-T)与结缔组织疾病(connective tissue diseases，CTD)损伤心脏的关系。方法 本实验以酶联免疫吸附法(ELISA)检测了99例CTD患者的血清Tn-I、Tn-T浓度，与正常对照组进行了比较，其阳性率与CK-MB、UCG、ECG阳性率进行了比较。结果 99例CTD患者，其中系统性红斑狼疮(SLE)组23例，原发干燥综合征(SS)组21例，类风湿关节炎(RA)组20例，混合结缔组织病(MCTD)组13例，多发性肌炎(PM)组13例，进行性系统性硬化症(PSS)组9例，同组血清Tn-I、Tn-T阳性率相同，分别为73.9%(17/23)、38.1%(8/21)、30.0%(6/20)、69.2%(9/13)、76.9%(10/13)、55.6%(5/9)，均较CK-MB、UCG、ECG阳性率高，且各组间比较有显著性差异(P＜0.05)。各组内Tn-I、Tn-T阳性率与ECG阳性率比较无显著性差异，与CK-MB、UCG阳性率比较，除PSS组外，均有显著性差异(P＜0.05)。各CTD组血清Tn-I、Tn-T浓度均增高，与正常对照组比较有显著性差异(P＜0.05)，SLE活动期Tn-I、Tn-T浓度较非活动期增高(P＜0.005)。结论 血清Tn-I、Tn-T浓度的检测可作为判断CTD损伤心脏的敏感指标，从而早期诊断CTD心脏受累，及早给予保护措施。
【关键词】 肌钙蛋白 结缔组织疾病 心脏损伤
Relationship between serum troponin and cardiac involvement in patients with connective tissue disease
LI Jin XIAO Chuanshi WANG Laiyuan et al
(Second Clinical Hospital,Shanxi Medical University,Taiyuan 030001)
【Abstract】 Objective To explore the relationship between levels of serum troponin I (Tn-I),troponin T (Tn-T) and cardiac involvement in connective tissue diseases (CTD).Methods Serum Tn-I and Tn-T concentrations were measured in 99 patients with CTD by an enzyme-linked immunosorbent assay (ELISA) and compared with normal controls.Positiverates of serum Tn-I and Tn-T were compared with those of CK-MB,UCG and ECG.Results All 99 patients with CTD consisted of 23 systemic lupus erythematosus (SLE),21 primary sjgren syndrome (SS),20 rheumatoid arthritis (RA),13 mixed connective tissue disease (MCTD),13 polymyositis (PM) and 9 progressive systemic sclerosis (PSS).The positive rates of serum Tn-I and Tn-T were 73.9%(17/23),38.1%(8/21),30.0%(6/20),69.2%(9/13),76.9%(10/13) and 55.6%(5/9) respectively in SLE,SS,RA,MCTD,PM and PSS groups,and were higher than those of CK-MB,UCG and ECG.There was significant difference among the 6 groups.There was no significant difference when positive rates of serum [1] [2] 下一页
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