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日本血吸虫感染后血清 型胶原水平的动态观察 |
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陈澍 翁心华 陆云 吴鸣鹤 施光峰
【摘要】 目的 了解血清Ⅵ型胶原在评估日本血吸虫病肝纤维化的程度及疗效中的作用。方法 对感染日本血吸虫的小鼠和59例经秋水仙碱或安慰剂治疗的晚期血吸虫病患者血清Ⅵ型胶原水平进行动态观察，同时对小鼠肝脏病理改变及患者肝脏B超和各临床指标作了观测。结果 小鼠血清Ⅵ型胶原水平在感染后进行性升高，并与肝脏病理变化基本一致；患者血清Ⅵ型胶原较正常人也有明显升高(P＜0.01)，但治疗组在治疗结束后有所下降，而对照组则显著升高，差异有显著性(P＜0.01)。结论 血清Ⅵ型胶原可能是监测血吸虫病肝纤维化进展及药物疗效的敏感指标。
【关键词】 Ⅵ型胶原 肝硬化 血吸虫病，日本
Monitoring of the serum collagen type Ⅵ in hepatic fibrosis of Schistosomiasis Japanicum Chen Shu, Weng Xinhua, Lu Yun, et al. Department of infectious diseases, Huashan Hospital, Shanghai Medical University, Shanghai 200040
【Abstract】 Objective In order to investigate the value of the surem collagen type Ⅵ in indicating hepatic fibrosis of Schistosomiasis japonic and effects of anti-fibrosis theraphy. Methods The levels of serum collagen type Ⅵ were mornitored in murine Schistosomiasis japonica and 59 Schistosomiasis patients treated with colchicine or placebo respectively, pathological changes of mice liver were detected as well as liver B-ultrosonic testing and other liver function tests were performed too.Results The levels of serum collagen type Ⅵ increased progressively in infected mice and consisted with pathological changes; colagen type Ⅵ levels in patients were higher than normal level too (P＜0.01). But after treatment collagen levels in treated group decreased slightly whereas increased obviously in control group, the difference were significantly (P＜0.01).Conclusion Serum collagen type Ⅵ maybe a sensitive marker for indicating hepatic fibrosis of Schistosomiasis japonica and for the assessment of the effects of anti-fibrosis agents.
【Key words】 Collagen type Ⅵ Liver cirrhosis Schitosomiasis japonica
日本血吸虫病肝纤维化程度的进展及药物疗效的评估，迄今仍无有效的方法。近年来对胶原等血清肝纤维化标志物的研究十分引人注目，并取得了一定的成绩。其中PⅢP、C-Ⅳ等胶原指标已在临床上广泛运用。但对血清C-Ⅵ的研究起步较晚，对它在疾病过程中的变化及临床意义所知甚少。我们分别对小鼠及晚血患者血清C-Ⅵ进行了动态观察，旨在明确血清C-Ⅵ在血吸虫病肝纤维化诊断及治疗监测中的价值。
材料与方法
一、实验动物
将雄性昆明种小鼠以日本血吸虫尾蚴40±5条经皮感染，并分批于感染后第3、5、7[1] [2] 下一页
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