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家族性2型糖尿病家系中红细胞膜钠 |
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兰帆 张素华 邱鸿鑫 兰雁飞 任伟 汪志红
【摘要】 目的 寻找家族性2型糖尿病(2型DM)的遗传标志。方法 采用Fujita等的红细胞膜钠-锂逆转换活性(SLCA)测定方法，测定了家族性2型DM家系中无并发症的22例家族性2型DM患者，27例2型DM患者的非糖尿病一级亲属，40例正常人的红细胞膜钠-锂逆转换活性。结果 家族性2型DM患者SLCA(0.310±0.101)mmol.L-1.RBC-1.h-1，2型DM的一级亲属SLCA(0.274±0.112)mmol.L-1.RBC-1.h-1，两者均显著高于正常对照组SLCA(0.191±0.083)mmol.L-1.RBC-1.h-1(P＜0.01)；家族性2型DM患者与其一级亲属之间SLCA无显著差异(P＞0.05)。分别以SLCA、胰岛素敏感指数(ISI)为应变量作逐步回归分析，发现ISI和高密度脂蛋白组分2(HDL2)与SLCA呈负相关(分别为P＜0.01、P＜0.05)，ISI、HDL2对SLCA的影响程度为42.5%，其中ISI对SLCA的影响程度为39.7%；并且SLCA参与ISI的变易，SLCA对ISI的影响程度为55.7%。结论 ①家族性2型DM患者及其一级亲属SLCA明显增高；②红细胞膜SLCA可能作为家族性2型DM的遗传标志及作为胰岛素敏感性的指标之一。
【关键词】 家族性2型糖尿病 胰岛素抵抗 一级亲属
Erythrocyte sodium-lithium counter-transport activity and insulin resistance in familial type 2 diabetes mellitus pedigrees
LAN Fan,ZHANG Shuhua,QIU Hongxin,et al.
Department of Internal Medicine,The First Affiliated Hospital of Chongqing Medical University,Chongqing,400016
【Abstract】 Objective To search for the inherited markers of familial type 2 diabetes mellitus. Methods Erythrocyte sodium-lithium counter-transport activity (SLCA) was measured according to the method described by Fujita in 22 familial type 2 DM patients (with 2 or more type 2 DM patients in the family), their 27 non-diabetic first-degree relatives, and 40 healthy control subjects. Results SLCA was significantly higher in familial type 2 DM patients 〔(0.310±0.101)mmol.L-1.RBC-1.h-1〕 and their non-diabetic first-degree relatives 〔(0.274±0.112)mmol.L-1.RBC-1.h-1〕 than in healthy control subjects 〔(0.191±0.083)mmol.L-1.RBC-1.h-1〕 (P＜0.01) ,no significant difference being found between familial type 2 DM patients and their first-degree relatives (P＞0.05). A stepwise multiple regression analysis was conducted using SLCA and insulin-sensitivity index (ISI) as the dependent variables respectively. It was found that SLCA correlated negatively with ISI and HDL2 (P＜0.01, P＜0.05, respectively)[1] [2] [3] 下一页
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