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血管紧张素转换酶基因多态性与2型糖尿病患者脑梗塞的关系 |
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段文澜 方京冲 杨海春 朱蔚珏 谢洁怡 杨秀芳 俞茂华 朱禧星
【摘要】 目的 探讨血管紧张素转换酶(ACE)基因多态性与2型糖尿病脑梗塞间的关系。方法 应用多聚酶链反应(PCR)技术，对109名2型糖尿病患者及52名正常对照者的ACE基因插入/缺失(I/D)型多态性进行检测，并用Logistic多元逐步回归，筛选出2型糖尿病患者脑梗塞的高危因素。结果 (1)糖尿病总组ACE 基因型频率和等位基因频率与正常对照组无 显著性差异(P＞0.05)。(2)糖尿病脑梗塞组ACE基因DD型和D等位基因频率显著高于非脑梗塞组(P＜0.01)及正常对照组(P＜0.05)。(3)多元逐步回归分析显示：ACE基因DD型、D等位基因、脂蛋白(a)及年龄是糖尿病脑梗塞的独立危险因素，而ACE基因II型和I等位基因则为2型糖尿病脑梗塞的保护因子。结论 ACE基因I/D多态性与2型糖尿病脑梗塞的发病密切相关。ACE基因I/D多态性检测对糖尿病脑梗塞的一级预防有一定的指导意义。
【关键词】 脑梗塞 糖尿病，2型 血管紧张素转换酶 基因多态性
Association between angiotensin-converting enzyme gene polymorphism and cerebral infarction in type 2 diabetic patients
DUAN Wenlan,FANG Jingchong,YANG Haichun,et al.
Diabetes Research Department,Huashan Hospital, Shanghai Medical University,Shanghai,200040
【Abstract】 Objective To investigate the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and cerebral infarction in type 2 diabetic patients. Methods ACE gene I/D polymorphism within intron 16 was determined by polymerase chain reaction (PCR) in 109 type 2 diabetic patients and 52 normal controls. Variables, including blood pressure, HbA1c, FMN, serum lipid profile, apoproteins, lipoprotein(a), serum C-peptide and ACE gene I/D polymorphism, were analyzed by multivariate stepwise logistic regression to determine the independent and significant risk factors for cerebral infarction in type 2 diabetic patients. Results (1)No significant difference in genotype and allele frequency of ACE gene was observed between type 2 diabetic patients and control group. (2)The DD genotype and D allele were more common in diabetic patients with cerebral infarction (0.43 and 0.60) than in those without cerebral infarction (0.13 and 0.37, P＜0.01) and control group (0.17 and 0.39, P＜0.05). (3) Multivariate stepwise regression analysis showed that DD genotype, D allele, lipoprotein(a), and age contributed significantly to cerebral infarction in ty[1] [2] [3] 下一页
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