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甲状腺局部自身免疫在桥本甲状腺炎癌变中的作用 |
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张昶 郑立农 徐金鑫
【摘要】 目的 探讨自身免疫因素在桥本甲状腺炎(HT)癌变中的作用。方法 用免疫组化ABC法对HT和HT癌变患者甲状腺内S-100蛋白阳性的树突状细胞(DC)，以及呈HLA-DR抗原阳性表达的细胞进行观察研究。结果 HT及HT癌变患者甲状腺内发现DC，HT的淋巴细胞型和嗜酸细胞型DC数量较纤维型为多，HT癌变的癌变区存在大量DC，数量明显多于HT病变区和HT，DC胞浆突起插入甲状腺上皮细胞(TEC)和癌细胞之间并与之接触，TEC及癌细胞呈不同程度DR阳性表达。结论 甲状腺内DC的存在及DR抗原阳性的细胞是引起自身免疫反应的始发和重要因素，HT及HT合并甲状腺癌中的TEC及癌细胞均受自身免疫因素影响，HT时甲状腺局部存在的自身免疫因素在HT癌变中起着重要作用，抑制自身免疫反应可预防HT癌变。
【关键词】 自身免疫 桥本甲状腺炎 癌变 甲状腺癌 树突状细胞 HLA-DR抗原
Role of local autoimmune factors of thyroid gland in malignant transformation of Hashimoto s thyroiditis
ZHANG Chang,ZHENG Linong,XU Jinxin.
The First People s Hospital of Huai Yin City,Huai Yin,223300
【Abstract】 Objective To study the role of autoimmune factors in malignant transformation of thyroid epithelial cells (TEC) in Hashimoto s thyroiditis (HT). Methods S-100 protein positive dendritic cells (DC) and HLA-DR antigen positive cells in thyroid glands from patients with HT and HT complicated with thyroid papillary carcinoma were studied by immunohistochemical method. Results DC were found in the thyroid glands from HT and HT complicated with thyroid papillary carcinoma. In HT, the numbers of DC of L-type and E-type were more than those of F-type. In HT with thyroid papillary carcinoma, there were a great number of DC in thyroid cancer areas and the number were much more than those of HT areas and HT. Dendritic projections of DC intervened between TEC and cancer cells and came into contact with them. TEC and cancer cells showed varying degree of DR antigen positive expression. Conclusion A great number of DC and DR antigen positive expression cells in the thyroid gland are primary and important factors causing autoimmune reaction. Both TEC and cancer cells in HT and HT complicated with thyroid cancer were under the influence of autoimmune factors. The local autoimmune factors in thyroid gland may play an important role in the malignant transformation of TEC in HT. Suppression of [1] [2] 下一页
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