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螺旋CT三维重建和多平面重建在骨关节损伤中的临床应用 |
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8th week of study, protein expressions of NF-κB、PKCα and PDGF-B in kidney were measured by immunohistochemistry, and 12-hour urine albuminuria excretion rate(UAER),plasma cholesterol,plasma triglyceride and plasma creatinine were determined with biochemistry .Results After 8 weeks ,the expressions of NF-κB,PKCα and PDGF-B in diabetic renal tissue were significantly increased(P<0.05). The means of UAER in diabetic control group was also significant different from other groups and was more than 90μg/min . The immunohistochemistry staining of NF-κB,PKCα and PDGF-B in kidney proximal tuble cytoplasma was more than that in glomeruler. Epithelial cells of kidney tuble were found vacuolar degeneration with hematoxylin-eosin staining(HE staining) by light microscopy . Both losartan and simvastatin could significantly inhibit the expressions of NF-κB,PKCα and PDGF-B in diabetic renal tissue(P<0.05),but could not make it recovery. Combined treatment of losartan and simvastatin could inhibit the expressions of NF-κB,PKCα and PDGF-B further. In general, effects between losartan and simvastatin were not significant difference.Conclusion NF-κB,PKCα and PDGF-B play an important action on the progression of diabetic nephropathy. It shouldn’t be ignored that they might injure kidney tuble . Both losartan and simvastatin have significant effect on diabetic nephropathy. The renoprotective effect of losartan is independent upon it’s effect of regulating lipoid metabolism. Combined treatment of losartan and simvastatin could further protect kidney from diabetic injury. But their exact mechanism remains to be further studied.
Key words losartan simvastatin diabetes nephropathy nuclear factor-kappa B protein kinase Cα isoenzyme platelet derived growth factor-B chain
通过观察NF-κB、PDGF-В、PKCα三种指标在STZ诱导的Wistar大鼠糖尿病对照、糖尿病用氯沙坦治疗、糖尿病用辛伐他汀治疗以及两药联合治疗4种条件下与正常对照大鼠肾小球、肾小管间质的免疫组化着色情况，进一步阐明肾脏局部RAS、PKCα、NF-κB、PDGF-В之间的联系以及氯沙坦、辛伐他汀肾脏保护作用的可能机制。
1 材料与方法
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