关键字:脑梗死患者血清胆红素及血脂变化的临床意义探讨
Clinical Significance of Serum Bilirubin and BloodLipid Level in Patients with Cerebral Infarction
WANG Zhongxiu,YANG Linhua,LIU Xiue,XUE Cunshui,LI Guanglai,ZHANG Yuan,YAN Wenlin
(The Second Hospital of Shanxi Medica1 University,Taiyuan,030001,China)Abstract: Objective To explore the change of serum bilirubin and bloodlipid level in patients with cerebral infarction.Methods Serum total bilirubin,direct bilirubin,indirect bilirubin, total cholesterol, triglycerides， serum highdensity lipoprotein cholesterol，serum lowdensity lipoprotein cholesterol，lipoproteina，apolipoprotein A1，apolipoprotein B was measured in 64 patients with cerebral infarction (the observed group) and 32 healthy controls.Apply SPSS 10.0 for windows to deal with all data, T test was used to compare between the groups.Results Serum bilirubin in patients in the observed group total bilirubin 16.464±7.442μmol/L,direct bilirubin 3.264±1.719 μmol/L,indirect bilirubin 13.201 ± 6.130 μmol/L was higher than the patients in the control group . P<0.01(TBIL), P<0.05 (IBIL);the level of indirect bilirubin was in positive correlation with the concentration of lowdensity lipoprotein cholesterol(r=0.213，P<0.05). Serum total cholesterol, triglycerides， serum highdensity lipoprotein cholesterol, apolipoprotein B was significantly increased in patients in the observed group (P<0.01),serum lowdensity lipoprotein cholesterol，apolipoprotein A1 in patients in the observed group was significantly decreased in the patients in the observed group(P<0.01).Conclusion It suggested that there were pathophysiological relationships between cerebral infarction and serum levels of bilirubin and bloodlipid.Key words: Cerebral infarction; Bilirubin; Bloodlipid
世界平均脑血管病的发病率为190～200/10万，而我国高达280/10万，其死亡率超过100/10万。近年来，随着人们对血红素氧合酶(HO)/一氧化碳(CO)胆红素系统研究的不断深入,发现传统观念对胆红素的认识不够完全。胆红素不只是体内的代谢产物,在一定的浓度下,它还是一种内源性
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