本实验证实IL17在感染衣原体后在固有性免疫反应应答早期短暂表达,随后很快下降,但其他细胞因子IL6,IL8,TNFα,IL1α,IL1β则分别在第3天或第8天出现高峰,基于这些资料我们认为IL17在衣原体肺炎早期出现,能提高局部IL6,IL8,TNFα,IL1α,IL1β的表达,表明IL17具有抗衣原体感染的免疫保护作用,进一步阐释了宿主感染衣原体后的免疫防御机制,对今后预防以及干预治疗衣原体感染性疾病提供了理论依据。
(致谢 本工作在美国得克萨斯大学圣安东尼奥健康科学中心微生物免疫系Dr.Zhong实验室完成)
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