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IL 17 在沙眼衣原体呼吸道感染中的早期表达及其与机体防御关系

  本实验证实IL17在感染衣原体后在固有性免疫反应应答早期短暂表达,随后很快下降,但其他细胞因子IL6,IL8,TNFα,IL1α,IL1β则分别在第3天或第8天出现高峰,基于这些资料我们认为IL17在衣原体肺炎早期出现,能提高局部IL6,IL8,TNFα,IL1α,IL1β的表达,表明IL17具有抗衣原体感染的免疫保护作用,进一步阐释了宿主感染衣原体后的免疫防御机制,对今后预防以及干预治疗衣原体感染性疾病提供了理论依据。

  (致谢 本工作在美国得克萨斯大学圣安东尼奥健康科学中心微生物免疫系Dr.Zhong实验室完成)

  【参考文献】

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  3 Kimura A,Naka T,Kishimoto T. IL6dependent and independent pathways in the development of interleukin 17producing T helper cells[J].Proc Natl Acad Sci USA,2007,104(29):1209912104

  4 Rouvier E,Luciani MF,Mattéi MG,et al. CTLA8,cloned from an activated T cell,bearing AUrich messenger RNA instability sequences,and homologous to a herpesvirus saimiri gene[J].J Immunol,1993,150(12):54455456

  5 Chabaud M,Fossiez F,Taupin JL,et al. Enhancing effects of IL17 on IL1induced IL6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines[J].J Immunol,1998,161(1):409 414

  6 Jovanovic DV,Battista JA,Martel PJ,et al.IL17 stimulates the production and expression of proinflammatory cytokines,IL1h and TNFa by human macrophages[J].J Immunol,1998,160(7):35133521

  7 Andoh A,Fujino S,Bamba S,et al. IL17 selectively downregulates TNFainduced RANTES gene expression in human colonic subepithelial myofibroblasts[J].J Immunol,2002,169(4):1683 1687

  8 Maertzdorf J,Osterhaus AD,Verjans GM.IL17 expression in human herpetic stromal keratitis:modulatory effects on chemokine production by corneal fibroblasts[J].J Immunol,2002,169(10):58975903

  9 Langrish CL,Chen Y,Blumenschein WM,et al.IL23 drives a pathogenic T cell population that induces autoimmune inflammation[J]. J Exp Med,2

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