您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文 　

连环素和 连环素在非小细胞肺癌中的表达及其临床意义

　　【摘要】 目的 探讨α连环素(αcat)和β连环素(βcat)在非小细胞肺癌(NSCLC)中的表达及其与NSCLC的发生、发展及临床预后的关系。方法 应用免疫组化法，观察43例NSCLC患者及7例正常肺组织中的αcat和βcat的表达。结果 在43例NSCLC中，αcat和βcat的异常表达率分别为72.1%和65.1%;αcat、βcat异常表达与不同病理分级间和淋巴结有无转移均有显著性差异(P<0.05);αcat和βcat异常表达者的生存时间明显少于正常表达者，βcat异常表达具有独立的预后意义(P<0.05，相对危险度RR=0.330)。结论 αcat和βcat表达与NSCLC的发生、发展及预后关系密切，可作为评估NSCLC进展及预后的指标。

　　【关键词】 肺肿瘤;α连环素;β连环素;免疫组织化学

　　nonsmall cell lung cancer and their clinical significanceDANG Xiaomin, SUN Zhongmin, SHANG Dong

　　(Department of Respiration, the First Affiliated Hospital,

　　Medical School of Xian Jiaotong University, Xian 710061, China)ABSTRACT: Objective To investigate the expressions of αcatenin (αcat) and βcatenin (βcat) and their relation with development and prognosis of nonsmall cell lung cancer (NSCLC). Methods Expressions of αcat and βcat were immunohistochemically studied in 43 specimens of NSCLC and 7 cases of normal lung tissues. Results Of the 43 NSCLC cases, the abnormal rate of αcat and βcat expression was 72.1% and 65.1%, respectively. Differentiation and lymph node involvement had a significantly positive correlation with abnormal expression of αcat or βcat (P<0.05). The survival time was significantly shorter in patients with αcat or βcat abnormal expression than in those with normal αcat or βcat expression. βcat could serve as an independent prognosis factor (P<0.05). Conclusion The expressions of αcat and βcat are closely correlated with the occurrence, development and prognosis of NSCLC. αcat and βcat may be used as indicators for development and prognosis of NSCLC.

　　KEY WORDS: lung neoplasm; αcatenin; βcatenin; immunohistochemistry

　　上皮细胞钙依赖黏附分子E钙黏素(Ecadherin)主要介导上皮细胞之间的连接和黏附，Ecadherin主要位于细胞膜上，与细胞膜内侧的连环素α、β结合成复合体，Ecadherincatenin(Ecadcat)复合体中任何组分结构和功能的异常均会影响细胞的黏附性[1]。近年来发现Ecadcat复合体功能异常与恶性肿瘤的侵袭转移、预后密切相关[2]。为此，我们应用免疫组化方法观察了αcat、βcat在非小细胞肺癌(NSCLC)中的表达，并探讨其表达与NSCLC发生、发展及预后的关系。

[1] [2] [3] [4] [5] 下一页


  • 上一个医学论文：

  • 下一个医学论文：
    • 相关文章
      氰基丙烯酸正丁酯栓塞治疗脑动静脉畸
    关于食管静脉曲张六连环套扎术的临床应
    Copyright © 2006-2012 绿色健康网(www.gio.org.cn) All Rights Reserved.
    声明：网站信息仅供参考，不能作为诊断及医疗的依据。