量的显著增多及5-HT含量的增加可能会导致大鼠肠道的过度运动,从而影响IBS-D大鼠大便的性状及内脏敏感性的改变。
综上所述,我们的研究结果表明肠肌间神经元内的5-HT含量及5-HT4受体数量的显著增多可能与IBS-D大鼠的发病相关;肠肌间神经元内的5-HT含量与IBS-C的发病无直接关系。
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