【摘要】 目的:探讨老年性下消化道大出血保守治疗策略。方法:我院2007年2月~2009年4月门诊及住院31例经胃镜证实为下消化道大出血患者,均予生长抑素首剂250μg静脉推注后,续以250μg/h的速度连续静滴72h,观察止血效果。结果:用药后24h、48h、72h止血率分别为61.3%、80.6%和87.1%,有效止血开始起效时间为(6.6±5.0)h,出血停止时间为(12.0±9.4)h。除1例患者首剂静脉推注时有一过性恶心、呕吐外,其余患者未见副作用。结论:生长抑素能安全、有效地治疗下消化道大出血。
【关键词】 下消化道大出血;抢救;生长抑素
Hemorrhage of lower digestive tract in 31 old patients
Yang Jianhui
(Department of Internal Medicine, Shipai Hospital in Dongguan Dongguan 523330, China)
[ABSTRACT] Objective: To explore effective treatments for hemorrhage of lower digestive tract in old patients. Methods: Thirtyone senile patients who visited our hospital during February 2007 and April 2009,and were confirmed as hemorrhage of lower digestive tract were treated with an initial dosage of 250μg somatoastatin, followed by a 72hour continuous infusion of 250μg /h. The treatment effects were observed. Results: Bleeding was under control in 61.3%、80.6% and 87.1% patients 24, 48 and 72 hours after the treatment. Time of initial effectiveness was (6.6±5.0) h, and time for complete control was (12.0±9.4)h. Only one case showed nausea and vomiting during the administration of the initial dosage of somatostatin. No other side effect was observed in any case. Conclusion: Somatostatin is effective and safe for treating hemorrhage of lower digestive tract.
[KEY WORDS] Hemorrhage of lower digestive tract; Rescue; Somatostatin
急性下消化道大出血发生率虽然明显低于急性上消化道大出血,但病因诊断比较困难,特别是小肠出血[1]。如:内镜检查难度大,患者不易耐受;放射性核素显像(ECT)在肠腔大量积血时定位准确性受影响;肠道钡餐检查在急性出血期列为禁忌,因此判断出血原因十分困难。
对于急性下消化道大出血手术高危人群,如年老体弱、合并多脏器病变、多系统功能衰竭或不愿接受手术的患者,积极进行内科保守治疗,把握抢救时机,可望提高抢救成功率。但临床观察发现,这类患者经常规输血、止血、制酸等治疗效果不佳。
我院2007年2月~2009年4月门诊及住院部经胃镜证实为下消化道大出血患者31例,均予生长抑素治疗,止血效果安全、有效,现报道如下。
1 资料与方法
1.1 一般资料
收集我院2007年2月~2009年4月门诊及住院部经胃镜排除十二指肠降部以上病灶,证实为下消化道大出血患者31例,其中男性22例,女性9例,年龄60~95岁,平均年龄(78±10.5)岁,体重40~73kg,平均(52±618)kg。经ECT、全消化道钡餐、肠镜检查或手术证实,31例患者中,空肠部位疾病引起出血8例、回肠部位疾病引起出血12
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