病毒感染在慢性阻塞性肺疾病急性加重中的作用

　　【摘要】目的 探讨常见呼吸道病毒感染在慢性阻塞性肺疾病急性加重(AECOPD)中的作用。方法 选择AECOPD患者116例，检测呼吸道病毒抗原及特异性IgM抗体，根据结果分为病毒阳性组及病毒阴性组。并对病毒阳性组与阴性组进行T淋巴细胞亚群检测。结果 116例AECOPD患者共检测出病毒阳性41例，阳性率为 35.34%。与病毒阴性组比较，病毒阳性组CD4+T淋巴细胞降低，CD8+T淋巴细胞升高，CD4+/CD8+比值下降，差异有统计学意义(P<0.05 或P<0.01)。结论 AECOPD与呼吸道病毒感染有关。病毒感染对T淋巴细胞亚群有抑制作用，导致机体细胞免疫功能低下。

　　【关键词】 慢性阻塞性肺疾病急性加重 呼吸道病毒 免疫功能

　　Effect of viral infection on the acute exacerbation of chronic obstructive pulmonary disease

　　CUI Wenjie, DING Ning, ZHOU Ning

　　(Department of Respiration, The First People′s Hospital, Xuzhou, Jiangsu 221002, China)

　　Abstract： Objective To investigate the effect of viral infections of the respiratory tract on the acute exacerbation of chronic obstructive pulmonary disease. Methods Samples from 116 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were tested for respiratory virus antigen and the specific IgM antibody for respiratory viruses. According to the results, patients were divided into virus-positive group and virus-negative group and their T lymphocyte subsets were tested and compared. Results Of the 116 AECOPD patients, 41 patients were found virus-positive, with a virus-positive percentage of 35.34%. In virus-positive group, the expressions of CD4+, CD4+/ CD8 were significantly lower than those in virus-negative group, with a higher CD8+ than in virus-negative group (P<0.05,P<0.01). Conclusion The AECOPD patients were related to viral infections of the respiratory tract. T lymphocyte subsets were associated with viral infections. The results also showed that viral infections could decrease immune functions and lead to immunologic aberration.

　　Key words: acute exacerbation of chronic obstructive pulmonary disease; respiratory virus; immunity function

　　慢性阻塞性肺疾病(COPD)是一种慢性呼吸系疾病，而COPD急性加重(AECOPD)是患者就医、住院、死亡的主要原因，慢性阻塞性肺病全球倡议(global initiative for chronic obstructive lung disease,GOLD)及我国COPD诊治指南均将预防和减少AECOPD列为治疗的长远目标之一。呼吸道

[1] [2] [3] [4] 下一页