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Klotho基因及其多态性的研究进展

.Clin Chim Acta,2006;371:6670.

  10 Riancho JA,Valero C,Hernandez JL,et al.Association of the F352V variant of the klotho gene with bone mineral density〔J〕.Biogerontology,2007;8:1217.

  11 Wakamatsu N,Kobayashi H,Miyatake T,et al.A novel exon mutation in the human betahexosaminidase beta subunit gene affects 3,splice site selection〔J〕.J Biol Chem,1992;267:240613.

  12 Liu W,Qian C,Francke U.Silent mutation induces exon skipping of fibrillin1 gene in Marfan syndrome〔J〕.Nat Genet,1997;16:3289.

  13 Arking DE,Becker DM,Yanek LR,et al.Klotho allele status and the risk of earlyonset occult coronary artery disease〔J〕.Am J Hum Genet,2003;72:115461.

  14 Arking DE,Atzmon G,Arking A,et al.Association between a functional variant of the klotho gene and highdensity lipoprotein cholesterol,blood pressure,stroke,and longevity〔J〕.Circ Res,2005;96:4128.

  15 Rhee EJ,Oh KW,Lee WY,et al.The differential effects of age on the association of klotho gene polymorphisms with coronary artery disease〔J〕.Metabolism,2006;55:134451.

  16 Ralston SH.Genetic control of susceptibility to osteoporosis〔J〕.J Clin Endocrinol Metab,2002;87:24606.

  17 Mullin BH,Wilson SG,Islam FM,et al.Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women〔J〕.Calcif Tissue Int,2005;77:14551.

  18 Zarrabeitia MT,Hernandez JL,Valero C,et al.Klotho gene polymorphism and male bone mass〔J〕.Calcif Tissue Int,2007;80:104.

  19 Rhee EJ,Oh KW,Yun EJ,et al.Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women〔J〕. J Endocrinol Invest,2006;29:6138.

  20 Rachel MF,Michael NW,David M,et al.The functional “KLVS” variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians〔J〕.BMC Medical Genetics,2006;7:51.

  21 Yamamoto M,Clark JD,Pastor JV,et al.R

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