【摘要】目的：评价奥曲肽治疗肝硬化并上消化道出血的疗效与安全性。方法：回顾性分析2002年1月～2007年12月肝硬化并上消化道出血住院患者24例,随机分成奥曲肽治疗组和传统治疗组，毎组各12例。奥曲肽治疗组先予奥曲肽0.1 mg静脉推注,然后以25 μg/h持续静脉滴注48～72 h;传统治疗组先予垂体后叶素20 U静脉推注,然后以15 U/h微泵维持48～72 h,并根据血压调节滴速;通过胃管观察各组的止血效果。结果：奥曲肽治疗组止血总有效率为91.67%，传统治疗组止血总有效率为50.00%，疗效有显著性差异(P<0.05);不良反应方面，奥曲肽治疗组发生率为16.67%，传统治疗组发生率为41.67%。结论：奥曲肽是治疗肝硬化上消化道出血的首选药物之一,且不良反应少。
【关键词】 肝硬化 胃肠出血 奥曲肽 垂体后叶素
Effect of Octreotide on the treatment of upper alimentary tract hemorrhage in liver cirrhosis
LIN Zhihui， SUN Xiaojuan
(1.Section 2, Department of Internal Medicine, Shanwei Yi-Hui Fund Hospital Shanwei 516000,China, 2. Department of Gastroenterology, the Second Affiliated Hospital of SUN Yat-SEN University Guangzhou 510000,China)
[ABSTRACT] Objective: To evaluate the efficacy and safety of octreotide on the treatment of upper alimentary tract hemorrhage complicated from liver cirrhosis. Methods: Twenty- four patients with upper alimentary tract hemorrhage complicated from liver cirrhosis from January 2002 to December 2007 were divided randomly into trial group(n=12)and control group(n=12), patients in trial group treated with octreotide 0.1 mg intravenous injection in bolus, and then 25 μg/h intravenous infusion continuously for 48～72 h, patients in control group treated with conventional regimen, using pituitrin 20 U intravenous injection in bolus first, and then 15 U/h intravenous infusion continuously for 48～72 h，the speed of infusion was regulated referencing to blood pressure. The effect of stanch bleeding was observed through nose-gastric tube. Results: The total effectual rates in group A and group B were 91.67% and 50.00% respectively, compared them, there was significant difference (P<0.05). The incidence of side effects in group A and group B were 16.67% and 41.67% respectively, compared them, there was significant difference (P<0.05). Conclusion: Octreotide is the primary drug for the treatment of gastrointestinal blee
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