【摘要】 目的：探讨支气管哮喘临床症状长期缓解患者肺功能与气道炎症的关系。方法：20例成年支气管哮喘临床缓解期患者行肺功能测定，酶联免疫吸附法(ELISA)测定外周血干扰素γ(IFNγ)、白细胞介素4(IL4)水平，并与47例健康体检者进行比较。结果：哮喘缓解期患者(FEV1/FVC)%<70%者13例，FEV1<80%预计值者14例，FEV1、PEF、FEF25、FEF50、FEF75显著低于对照组(P<0.01)。哮喘患者血浆IL4水平显著高于对照组(P<0.01)，IFNγ/IL4显著降低(P<0.05)。IFNγ/IL4与FEV1、PEF呈显著负相关 (P<0.01)。结论：临床症状长期缓解的哮喘患者仍可能存在肺功能损害，气道炎症和Th1/Th2平衡紊乱持续存在。
【关键词】 支气管哮喘;IFNγ;IL4;肺功能
Correlation between Pulmonary Function and Airway Inflammation in Long Term Remission Patients with Bronchial Asthma YANG Zhongwei,JIN Weiguo*,XUE Keying,WANG Chengguo (Department of Respiratory Disease,Dongfeng Hospital,Yunyang Medical College,Shiyan,Hubei 442008,China)
Abstract:Objective To investigate the correlation between pulmonary function and the levels of inflammatory factors in serum of long term remission patients with bronchial asthma.Methods The pulmonary function were determined in 20 cases of adult asthmatic patients with long term remission,the serum levels of IFNγ and IL4 in those patients were determined with ELISA，47 cases of healthy volunteers were selected as control group.Results There were 13 cases that the values of (FEV1/FVC)% were lower than 70% and 14 cases that the values of FEV1 were lower than 80% predicted value in 20 asthmatic patients,and FEVl,PEF,FEF25,FEF50,FEF75 were all significantly lower than those of control group(P<0.01).The serum level of IL4 was significantly higher than that of control group(P<0.01),IFNγ/IL4 was significantly decreased(P<0.05).IFNγ/IL4 were negatively correlated with both FEV1 and PEF (Pall<0.01).Conclusion Although through a long term remission,the pulmonary function injury,airway inflammation and imbalance of Th1/Th2 may still exist in asthmatic patients.
Key words： Bronchial asthma;Interferonγ;Interleukin4;Pulmonary function
气流受限和反复发作是支气管哮喘的临床特征之一，部分哮喘患儿随着年龄的增长及较长时间治疗后，症状体征消失，病情得到控制并维持一段相对较长的临床稳定期。然而，由于缺少青少年期肺功能检查的动态资料，部分患者成年后无法判定其肺功
[1] [2] [3] [4] 下一页
您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文