【摘要】目的 观察应用奥曲肽联合奥美拉唑治疗食管、胃底静脉曲张出血的疗效。方法 患者分为2组，每组30例，A组予以奥曲肽25 mg/h静滴，每日用量600 mg;奥美拉唑40 mg静脉滴注，每日2次。B组予奥曲肽25 mg/h静脉滴注，每日用量600 mg。结果 两组治疗前基本资料相似，具可比性。止血时间A组(14.2±12.6)h，明显快于B组(21.4±19.6)h(P<0.05)，6、12、24、48、72 h止血率A组为50%、70%、80%、86.7%、93.3%，明显高于B组36.7%、53.3%、70%、76.7%、80%，(P<0.05和0.01)。治疗总有效率：A组为93.3%，明显高于B组80%(P<0.01)。再出血率：A组10.0%，明显低于B组的23.3%(P<0.05)。两组均未发生明显不良反应。结论 奥曲肽联合奥美拉唑治疗食管胃底静脉曲张出血，疗效可靠值得推广应用。
【关键词】 奥曲肽;奥美拉唑;食管胃底静脉曲张出血;肝硬化
Observation on effect of omeprazole and octreotide in treating oesophagastric bottom varicosity
YANG Cong-lin.The Madao Branch of The Frist Hospital’s of Liangshan Autonomous Region，Xichang 615031，China
[Abstract] Objective To observe the effect of omeprazole and octreotide in curing oesophagastric bottom varicosity.Methods The patients were dividedinto two groups.Group A used octreotide 25 mg/h mainline，600 mg everday;then omeprazole 40 mg mainline twice a day.Group B used octreotide 25 mg mainline and 600 mg everyday.Results The basic material was similar of the two groups.The hemostasis time of group A was(14.2±12.6)h.which was shorter than that of group B[(21.4±19.6)h](P<0.05).The hemostasis rates were 36.7%，53.3%，70%，76.7%，50% after 6，12，24，48，72 h，respectively(P<0.05，0.01)，which were obviously higher than that of group B.The total effective rate:group A was 93.3%，group B was 80%(P<0.01).Rehemorrhagic rate:group A was 10.0%，group B was 23.3%(P<0.05).There was no obvious side effect in both the groups.Conclusion The combination uses of omeprazole and octreotide in treating oesophagastric bottom varicosity is a effictive method，worth of extending application.
[Key words] octreotide;omeprazole;Oesophagus and gastric bottom varicosity Haemorrhagia;Cirrhosis
食管胃底静脉曲张出血是肝硬化严重并发症，来势凶，出血量大，死亡率高达50%。生长抑素及其类似药物被广泛用于肝硬化食管胃底静脉曲张出血，并已取得较为满意的效果[1]。2004年1月～2006年6月，笔者应用奥曲肽联合奥美拉唑治疗食管胃底静脉曲张出血30例，取得满意疗效，现报告如下。
1 对象与方法
1.1 研究对象 2004年1月～2006年6月凉山州第
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