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血浆脂联素水平与冠脉病变及PWV ABI的关系研究 |
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【摘要】 目的 观察冠心病（CHD）患者血浆脂联素（APN）水平，踝臂指数（ABI）和脉搏波传导速度（PWV）并探讨它们与冠脉病变之间的关系。方法 选取在本院心内科行冠脉造影的住院病人98例，53例诊断为急性冠脉综合征(ACS)，22例诊断为稳定性心绞痛（SAP）；23例冠脉造影正常者为对照组；采用酶联免疫法检测APN水平，动脉硬化检测仪检测ABI，PWV。结果 ACS组APN水平低于正常对照组（P＜0.01）低与SAP组（P＜0.05），经冠脉造影证实的冠心病组APN低于正常对照组（P＜0.01），其中三支病变组血浆脂联素水平低于单支及双支病变组，均有统计学意义；APN越低，PWV值越大，ABI水平越低。结论 CHD病人血浆APN水平明显降低，APN的降低与冠脉狭窄程度,冠脉斑块的稳定性有密切关系。APN可能是冠心病的一个新的独立危险因子，它与ABI、PWV联合在评估冠心病患者冠脉病变程度及危险性方面具有重要意义。
【关键词】 脂联素；急性冠脉综合征；稳定性心绞痛；踝臂指数；脉搏波传导速度
The Relationship between Plasma Adiponectin Concentration and Pulse Wave Velocity、 Ankle Brachial Index、the Severity of Coronary Artery Lesion in Coronary Heart Disease. LIU Bo_qin, AN Yi, CAO Guang_zhi, et al. Department of Cardiology, the Affiliated Hospital of Medical College, Qingdao University, Shandong 266061, China
［Abstract］ Objective To explore the relationship between plasma adiponectin concentration(APN) and the ankle brachial index(ABI) 、the pulse wave velocity (PWV), the severity of coronary artery lesion in coronary heart disease (CHD). Methods A total of 98 subjects who attended the cardiovascular department of the affiliated hospital of Qingdao university medical college from Aug 2007 to Jun 2008 were enrolled. The subjects were divided into normal control group (n=23)、ACS group(acute coronary syndrome, n=53) and SAP group(sta[1] [2] [3] [4] [5] [6] 下一页
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