|
2型糖尿病初发患者外周血单核细胞中核因子 kB 表达及超敏C反应蛋白水平研究 |
| |
【摘要】 目的 探讨2型糖尿病(T2DM)初发患者外周血单核细胞中核因子kB(NF_kB)的表达及血清超敏C反应蛋白水平(hs-CRP)。方法 颗粒增强免疫沉淀法测定91例初发T2DM患者(G2组)及60例对照组(G1组(血清超敏C反应蛋白水平(hs_CRP)水平；免疫组织化学染色法测定G2、G1组外周血单核细胞NF_kB活性；分析NF_kB活性与hs_CRP浓度相关性。结果 G2组外周血单核细胞中NF_kB活性和血清hs_CRP水平显著高于G1组(P＜0.01)，而且外周血单核细胞中NF_kB活性与血清hs_CRP水平显著正相关。结论 2型糖尿病患者处于炎症状态，血单核细胞中核因子NF_kB表达及血清hs_CRP水平升高可能与动脉粥样硬化的形成有关。
【关键词】 2型糖尿病；核因子_kB；超敏C反应蛋白
Changes of Nuclear Factor_κB Activity in Peripheral Mononuclear Cell and Serum High_Sensitivity C Reactive Protein in Newly Diagnosed Type 2 Diabetes (T2DM). LOU Da_jun, ZHU Qi_qian, SI Xu_wei. Department of Endocrinology, Shaoxing People's Hospital, Zhejiang 312000, China
［Abstract］ Objective To investigate the changes of Nuclear Factor_κB (NF_κB) in peripheral mononuclear cell and serum High_sensitivity C reactive protein (hs_CRP) in T2DM. Methods Immunohistochemical method was used to measure activity of NF_κB in peripheral blood mononuclear cell and immunolurbidimelric assay was used to measure hs_CRP in 91 T2DM and 60 normal control subjects (control group). At the same time linear correlation analysis was used to analyze the correlation between the level of hs_CRP and the level of NF_κB activity. Results The expression level of NF_κB in peripheral mononuclear cell and serum&nb[1] [2] [3] [4] [5] 下一页
上一个医学论文： 颈动脉内膜中层厚度和血清胆红素水平的关系
下一个医学论文： 脑出血大鼠脑内胚胎神经干细胞移植的运动神经功能改变和形态学研究
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 内科论文 >> 正文