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急性白血病抗凝纤溶异常的临床意义 |
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【摘要】 目的 观察急性白血病(AL)患者抗凝纤溶指标的变化以探索其在AL诊断、治疗及预后判断中的意义。方法 采用STAR全自动血凝仪对58例急性白血病患者血浆中抗凝血酶(AT)活性、抗纤溶酶(AP)活性及纤溶酶原(PLG)活性定量检测,并将结果与正常对照组进行比较。结果 对照组与患者组各期(治疗前、治疗中、复发期)AT、AP、PLG的差异有统计学意义(H=25.509,P<0.05),与缓解期比较差异无统计学意义(P>0.05),出血组高于无出血组,差异有统计学意义(P<0.05 ),急淋组与急非淋组差异无统计学意义(P>0.05)。结论 急性白血病患者存在抗凝纤溶功能异常,抗凝纤溶功能异常是导致AL出血的重要原因,可随病情好转逐渐改善,AT、aP 、PLG在指导治疗和判断预后中具有重要价值。 【关键词】 白血病; 抗凝血酶; 抗纤溶酶; 纤溶酶原
Clinical Sgnificance of Abnormal Anticoagulation and Fibrinolysis in Patients with Acute Leukemia
KONG Jinxing ,TONG Li ,SHI Hongqiong ,XU Yunmin
(Department of Laboratory, the 1st Affiliate Hospital of Kunming Medical College,Kunming 650032,China)
Abstract: Objective To observe the changes of anticoagulation and fibrinolysis markers in patients with acute leukemia (AL), and explore its significance in diagnosing, treatment and prognosis.Methods Serum levels of antithrombin (AT), antiplasmin (AP) and plasminogen (PLG) were determined with automated coagulation analyzer STAR in 58 AL patients and compared with the levels in normal control group.Results The difference of the levels of AT, AP and PLG in AL patients before, during the treatment and in relapse showed statistical significance (H=25[1] [2] [3] [4] [5] 下一页 上一个医学论文: 血浆蛋白Z水平测定的临床观察 下一个医学论文: 抗磷脂综合征分类标准修订的国际意见声明
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