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血浆蛋白Z水平测定的临床观察 |
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【摘要】 目的 检测蛋白质Z(PZ)在重症肝病与口服华法林患者中的变化,探讨其临床意义。方法 血浆PZ采用ELISA法检测,凝血因子活性FX:C和PT(INR)应用全自动血凝仪测定;对17例重症肝病、30例口服华法林和23例健康者的血浆PZ、FX:C和PT(INR)水平进行检测,并做各组相关性作比较。结果 重症肝病组和口服华法林组的PZ水平分别为240.1±192.7 μg/L、609.9±267.2 μg/L与对照组的1 812.6±34.2 μg/L比较明显下降(P值均<0.05);重症肝病组与口服华法林组的FX:C分别为71.4±30.2%、85.±19.5%,与对照组FX:C的 110.6±17.0比较,明显下降(P<0.05).;而PT(INR)分别为2.22±0.97;2.45±0.63与对照组0.93±0.04比较,明显增高(P<0.05)。结论 同时检测PZ与PT(INR)① 有助于重症肝病患者治疗的预后监控;② 对口服华法林患者可能发生的出血危险性的预测有重要意义。 【关键词】 重症肝病; 华法林; 蛋白Z
Detection of Plasma Protein Z Level and the Clinical Oberservation
ZHANG liao.TANG Rong hua
(Laboratory,YiJishan Hospital to Wan Nan Medical College, Wuhu 241001,China)
Abstract: Objective To observe the alteration of protein Z(PZ) in patients with severe hepatopethy (SH) or oral warfarin therapy (OWT) and to explore Its chinical significance.Methods PZ was measured by ELISA, plasma FX:C and PT:NR by automatic coagulation analysator. In 17 patients with Severe hepatopathy (SH.),30 patients with oral warfarin therapy (OWT )and 23 healthy persons as contrast;plasma PZ, FX:C , and PT(INR) were measured and compared with those in different groups.Results In SH and OWT groups, PZ levels decreased signi[1] [2] [3] [4] [5] 下一页 上一个医学论文: 获得性血管性血友病的研究进展 下一个医学论文: 急性白血病抗凝纤溶异常的临床意义
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