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突变型早老素与Alzheimer病

1 regulates the pro cessing o f beta-amyloid precursor protein C-terminal fragments and the generation of am yl oid beta-protein in endoplasmic reticulum and Golgi. Biochemistry,1998,37:1645 -16471.

  15,Kosik KS. Presenilin interactions and Alzheimr s disease. Science, 19 98, 279:463-465.

  16,Holcomb L, Gordon MN, McGowan E, et al. Accelerated Alzheimer-type phenotype i n transgenic mice carrying both mutant amyloid

precursor protein and presenilin 1 transgenes. Nat Med, 1998,4:97-100.

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gg M, Hutton M, Talbot C. Genetic association between intronic pol ymorphism in presenilin-1 gene and late-onset Alzheimer s disease. Lancet, 1996,347:509 -512.

  18,Takashima A, Murayama M, Murayama O, et al. Presenilin 1 associates w ith glyco gen synthase kinase-3 beta and its substrate tau. Proc Natl Acad Sci USA, 1998, 95:9637-9641.

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