您现在的位置: 绿色健康网 >> 医学论文 >> 内科论文 >> 正文  

突变型早老素与Alzheimer病

ane spanning topogr aphy of the Alzheim er disease-related presenilin proteins in the plasma membranes of cultured cell s. Proc Natl Acad Sci U S A, 1997,94:14025-14030.

  4,Kim TW, Pettingell WH, Jung YK, et al. Alternative cleavage o f Alzheimer-associ ated presenilins during apoptosis by a caspase-3 family protease. Science,1997, 277 :373-376.

  5,Sisodia SS, Thinakaran G, Borchelt DR, et al. Function and dy sfunction of prese nilins in Alzheimer s disease. In: Iqbal K, Swaab DF, Winblad B, et al, eds. Alz heimer s disease and related disorders. 1st ed. Chichester:John Wiley & Sons LTD ,1999.333-346.

  6,Li J, Xu M, Zhou H, et al. Alzheimer presenilins in the nucle ar membrane,interp hase kinetochores, and centrosomes suggest a role in chromosome segregation. Cel l, 1997, 90:917-927.

  7,de Strooper B, Annaert W, Cupers P, et al. A presenilin-1-d ependent gamma-secre tase-like protease mediates release of Notch introcellular domain. Nature, 1999 ,398: 518-522.

  8,Struhl G, Greenwald AI. Presenilin is required for activity a nd nuclear access of Notch in Drosophila. Nature, 1999, 398: 522-525.

  9,Ye Y, Lukinova N, Fortini ME. Neurogenic phenotypes and alter ed Notch processing in Drosophila presenilin mutants. Nature, 1999, 398:525-529.

  10,Li X, Greenwald I. Additional evidence for an eight-transmembrane-d omain topol ogy for Caenorhabditis elegans and human presenilins. Proc Natl Acad Sci USA, 19 98, 95:7109-7114.

  11,De-Strooper B, Saftig P, Craessaerts K, et al. Deficiency of prese nilin-1 inhi bits the normal cleavage of amyloid precursor protein. Nature, 1998, 391:387-39 0.

  12,Hardy J, Israel A. Alzheimer s disease. In search of gamma-secretase . Nature, 1999, 398: 466-467.

  13,Zhang Z, Hartmann H, Do VM, et al. Destabilization of beta-catenin b y mutatio ns in presenilin-1 potentiates neuronal apoptosis. Nature, 1998, 395:698-702.

  14,Xia W, Zhang J, Ostaszewski BL, et al. Presenilin

上一页  [1] [2] [3] [4] [5] 下一页


  • 上一个医学论文:

  • 下一个医学论文:
  • 相关文章
    唾液中口腔粘膜上皮细胞FMR1基因突变的
    遗传性脊髓小脑型共济失调的CAG三核苷
    非小细胞肺癌中p16基因的突变研究
    先天性尿道下裂与SRD5A2及SRY基因突变
    一个母系遗传非综合征耳聋大家系及mtD
    中国西北三省区 地中海贫血的基因突变
    伴有低外显率的Rb基因点突变及其特征和
    Wilson病ATP7B基因Arg778Leu突变与临床
    昆明山海棠诱导人白血病细胞HPRT基因突
    黄瓜黄绿叶突变性状的遗传分析
    线粒体tRNAleu UUR 基因突变和细胞色素
    猪雌激素受体基因 ESR 点突变的PCR SS
    简述线粒体电压依赖阴离子通道对携带线
    Copyright © 2006-2012 绿色健康网(www.gio.org.cn) All Rights Reserved.
    声明:网站信息仅供参考,不能作为诊断及医疗的依据。