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血浆组织因子和血管内皮因子在颌面部恶性肿瘤中的变化 |
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【摘要】 目的 观察颌面部恶性肿瘤患者血浆组织因子(TF)和血管内皮生长因子(VEGF)水平的变化并探讨其临床意义。方法 运用ELISA法检测40例颌面部恶性肿瘤患者及20例良性肿瘤患者血浆TF和VEGF水平,并与正常对照组进行比较。结果 颌面部恶性肿瘤患者血浆TF和VEGF明显高于正常对照组和良性肿瘤组(P<0.01);伴有其他脏器转移的颌面部恶性肿瘤患者血浆TF和VEGF水平较无其他脏器转移者增高(P<0.05);颌面部恶性肿瘤患者血浆TF升高与VEGF增加呈正相关(r=0.51,P<0.01)。结论 TF和VEGF在颌面部恶性肿瘤的生长和转移中起重要的作用,并可作为鉴别良、恶性肿瘤及指导预后的辅助指标。
【关键词】 组织因子; 血管内皮生长因子; 颌面部肿瘤
Variations of Plasma Tissue Factor and Vascular Endothelial Growth Factor in Patients with Oral and Facial Tumors
DOU Hong-ju1,ZOU Li-fang1,Tang YONG1,WANG Lei1,Wang Xue-feng2,HU Jun-pei1
(1.Department of Hematology,Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China; 2.Shanghai Institute of Hematology, Shanghai 20025,China)
Abstract: Objective To observe the variations of plasma tissue factor (TF) and vascular endothelial growth factor (VEGF) in the patients with oral and facial malignant tumors and to explore clinical significance.Methods Plasma levels of TF and VEGF were measured by ELISA technique in 40 patients with oral and facial malignant tumors and 20 patients with benign tumors, which compared with 25 normal controls (healthy volunteers).Results Plasma levels of TF [1] [2] [3] [4] 下一页 上一个医学论文: 冠心病合并慢性心力衰竭患者血管性血友病因子水平的变化 下一个医学论文: 肝移植术后早期腹腔出血及其处理的探讨
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