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冠心病合并慢性心力衰竭患者血管性血友病因子水平的变化 |
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【摘要】 目的 探讨冠心病合并慢性心力衰竭患者血清中血管性血友病因子(von Willebrand factor,vWF)的变化和临床意义。方法 选取确诊冠心病患者57例和同期健康人30例作为对照组,抽取静脉血,采用酶联吸附法测定血清中vWF含量,并按心功能等级分级进行比较分析。结果 冠心病合并慢性心力衰竭患者血清中vWF显著升高(P<0.01),并随着心衰加重而越显著(P<0.01),心功能Ⅲ、Ⅳ级与Ⅱ级比较显著升高(P<0.01),心衰程度与血清中vWF呈正相关关系(r=0.43, P<0.01)。结论 冠心病合并慢性心力衰竭患者血清中vWF水平升高,检测血清中vWF可作为评价其病情严重程度的指标之一。 【关键词】 冠心病; 心力衰竭; 血管性血友病因子
Change of von Willebrand Factor in Patients with Coronary Heart Disease in Association with Heart Failure
ZHANG Wei ,PAN Xue-yi,GUO Shu-zhu,XU Li-mei
(The First Affiliated Hospital of Guangdong University of Pharamcy ,Guangzhou,510080,China)
Abstract: Objective To investigate the change and significance of von Willebrand factor (vWF) in patients with coronary heart disease in association with heart failure.Methods The level of vWF in plasma of 57 patients with coronary heart disease in association with heart failure and 30 normal persons were determined .According to the heart function the patients were divided into three groups.Results The plasma levels of vWF of patients with coronary heart disease in association with heart failure were significantly higher than control group (P<0.01),the poorer the hear[1] [2] [3] [4] 下一页 上一个医学论文: 颈动脉支架置入术后循环血小板活化和聚集的系列变化 下一个医学论文: 血浆组织因子和血管内皮因子在颌面部恶性肿瘤中的变化
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