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颈动脉支架置入术后循环血小板活化和聚集的系列变化 |
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selectin quantified by enzyme-linked immunosorbent assay were determined in twenty patients with symptomatic carotid stenosis undergoing CAS. Blood samples were obtained immediately before stent implantation and 0.5 h,18 h,6 d after the procedure respectively. All twenty patients were on dual antiplatelet therapy of aspirin and clopidogrel before CAS, and all patients were stented with embolic protection devices.Results Soluble CD 40 ligand levels increased from 0.8(0.23～2.38)ng/ml before procedure to 2.35(1.14～5.38)ng/ml,4.10(2.27～6.91)ng/ml at 18 h and 6 d after the procedure respectively （P<0.05）. Similary, soluble P-selectin levels increased from 54.46±28.53 ng/ml before procedure to 73.03±35.4 ng/ml at 6 d after the procedure（P<0.05）. Circulation platelet-monocyte aggregates,fibrinogen receptors and the maximum platelet aggregation rate, however, were not changed after the procedure.Conclusion Elevated serum soluble CD 40 ligand and soluble P-selectin levels indicate the occurrence of platelet activation after CAS, despite treatment with dual antiplatelet therapy before CAS and the application of embolic protection devices during the procedure.
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